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After the end of resorption, however, the resorbed enamel surface is repaired by the deposition of a cementum\u2010like tissue. Using this phenomenon as an observation model, in this study we examined the sequence of cellular and extracellular\/matrix events involved in the enamel resorption repair by light and electron microscopy. As the odontoclast terminated its resorption activity, it detached from the resorbed enamel surface; thereafter, numerous mononuclear cells were observed along the resorbed enamel surface. Most of these mononuclear cells made close contact with the resorbed enamel surface, and coated pits or patches were observed on their plasma membrane facing this surface. Furthermore, they frequently contained thin needle\u2010 or plate\u2010like enamel crystals in their cytoplasmic vacuoles as well as secondary lysozomes. Following the disappearance of these monononuclear cells, the resorbed enamel surface now displayed a thin coat of organic matrix. Ultrastructurally, this organic layer was composed of a reticular and\/or granular organic matrix, but contained no collagen fibrils. Energy\u2010dispersive X\u2010ray microanalysis of this thin organic layer in undecalcified sections revealed small spectral peaks of Ca and P. Cementum\u2010like tissue initially formed along this thin organic layer, increased in width, and appeared to undergo mineralization as time progressed. The results of our observations demonstrate that regardless of type of matrix of dental hard tissues, tooth repair may be coupled to tooth resorption, and suggest that mononuclear cells and an organic thin layer found on the previously resorbed enamel surface may play an important role in the repair process initiated after resorption of the enamel. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.a.20069","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T14:04:24Z","timestamp":1089122664000},"page":"779-791","source":"Crossref","is-referenced-by-count":11,"title":["Cementum\u2010like tissue deposition on the resorbed enamel surface of human deciduous teeth prior to 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