{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:47:06Z","timestamp":1767980826231,"version":"3.49.0"},"reference-count":172,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver progenitor cells as well as hepatic stellate cells have neuroendocrine features. Progenitor cells express chromogranin\u2010A and neural cell adhesion molecule, parathyroid hormone\u2010related peptide, S\u2010100 protein, neurotrophins, and neurotrophin receptors, while hepatic stellate cells express synaptophysin, glial fibrillary acidic protein, neural cell adhesion molecule, nestin, neurotrophins, and their receptors. This phenotype suggests that these cell types form a neuroendocrine compartment of the liver, which could be under the control of the central nervous system. We recently showed that the parasympathetic nervous system promotes progenitor cell expansion after liver injury, since selective vagotomy reduces the number of progenitor cells after chemical injury in the rat. Similarly, after transplantation, which surgically denervates the liver, human livers that develop hepatitis have fewer progenitor cells than native, fully innervated livers with similar degrees of liver injury. There is also accumulating experimental evidence linking the autonomic system, in particular the sympathetic nervous system (SNS), with the pathogenesis of cirrhosis and its complications. Recently, it has been shown that hepatic stellate cells themselves respond to neurotransmitters. Moreover, inhibition of the SNS reduced fibrosis in carbon tetrachloride\u2010induced liver injury. In view of the denervated state of transplanted livers, it is very important to unravel the neural control mechanisms of regeneration and fibrogenesis. Moreover, since there is a shortage of donor organs, a better understanding of the mechanisms of regeneration could have therapeutic possibilities, which could even obviate the need for orthotopic liver transplantation. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.a.20096","type":"journal-article","created":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T13:23:56Z","timestamp":1093353836000},"page":"910-923","source":"Crossref","is-referenced-by-count":71,"title":["Neuroregulation of the neuroendocrine compartment of the liver"],"prefix":"10.1002","volume":"280A","author":[{"given":"Tania","family":"Roskams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cassiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Libbrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,24]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1333","article-title":"Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat","volume":"137","author":"Abdel\u2010Aziz G","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80431-X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899068"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80185-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90038-F"},{"issue":"1","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1523\/JNEUROSCI.15-01-00511.1995","article-title":"Overexpression of synaptophysin enhances neurotransmitter secretion at Xenopus neuromuscular synapses","volume":"15","author":"Alder J","year":"1995","journal-title":"J Neurosci"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80111-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80165-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.1996.tb00982.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/35018642"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2001.210601.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119655"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-5-1112"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1990.tb19475.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00260-X"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890000"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90040-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90127-W"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092260313"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1139\/o89-121"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711670210"},{"key":"e_1_2_10_23_1","first-page":"557","article-title":"Brain\u2010derived neurotrophic factor, neurotrophin\u20103, and neurotrophin\u20104 act as \u201cepitheliotrophins\u201d in murine skin","volume":"79","author":"Botchkarev VA","year":"1999","journal-title":"Lab Invest"},{"key":"e_1_2_10_24_1","first-page":"82","article-title":"The plasma cholinesterases: a new perspective","volume":"22","author":"Brown SS","year":"1981","journal-title":"Adv Clin Chem"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711500106"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-5-2218"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19990515\/01)45:4\/5<217::AID-JEMT5>3.0.CO;2-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65501-0"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20793"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00122-2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00263-5"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00260-4"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64208-3"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-11-06571.1994"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00036-2"},{"key":"e_1_2_10_36_1","first-page":"771","article-title":"Immunolocalization of putative human liver progenitor cells in livers from patients with end\u2010stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV\u20106","volume":"152","author":"Crosby H","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.20.6942"},{"key":"e_1_2_10_38_1","first-page":"1606","article-title":"Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D\u2010galactosamine model of liver regeneration","volume":"143","author":"Dabeva MD","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-204-43660"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(97)00165-2"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(98)90092-0"},{"key":"e_1_2_10_42_1","first-page":"773","article-title":"Extracellular matrix components induce endocrine differentiation in vitro in NCI\u2010H716 cells","volume":"142","author":"de Bruine AP","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.2000.0240"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-3-3-503"},{"key":"e_1_2_10_45_1","unstructured":"DemetrisAJ SeabergEC et al.1993.Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes.149:439\u2013448."},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(02)00900-1"},{"key":"e_1_2_10_47_1","first-page":"1441","article-title":"Ultrastructural characteristics of novel epithelial cell types identified in human pathological liver specimens with chronic ductular reaction","volume":"140","author":"De Vos R","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711670209"},{"key":"e_1_2_10_49_1","first-page":"309","article-title":"Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury","volume":"147","author":"Donovan MJ","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-3-10-1589"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31166"},{"key":"e_1_2_10_52_1","first-page":"4887","article-title":"Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas","volume":"49","author":"Dunsford HA","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_10_53_1","first-page":"4894","article-title":"Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies","volume":"49","author":"Dunsford HA","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb06995.x"},{"key":"e_1_2_10_55_1","first-page":"1337","article-title":"A precursor\u2010product relationship exists between oval cells and hepatocytes in rat liver","volume":"11","author":"Evarts RP","year":"1987","journal-title":"Carcinogenesis"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.10.2143"},{"key":"e_1_2_10_57_1","first-page":"142","article-title":"Similarities in the sequence of early histologic changes induced in the liver of the rat by ethionine, 2\u2010acetylaminofluorene, and 3\u2032\u2010methyl\u20104\u2010dimethylaminoazobenzene","volume":"16","author":"Farber E","year":"1956","journal-title":"Cancer Res"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(90)90153-6"},{"key":"e_1_2_10_59_1","first-page":"1501","volume-title":"The liver: biology and pathobiology","author":"Fausto N","year":"1994"},{"key":"e_1_2_10_60_1","first-page":"2532","article-title":"Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor","volume":"5","author":"Frucht H","year":"1999","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_61_1","first-page":"511","article-title":"Expression of stem cell factor and its receptor, c\u2010kit, during liver regeneration from putative stem cells in adult rat","volume":"70","author":"Fujio K","year":"1994","journal-title":"Lab Invest"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880029"},{"key":"e_1_2_10_63_1","first-page":"601","article-title":"In situ distribution of enolase isozymes in chronic liver disease","volume":"84","author":"Fukuda Y","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(85)80073-4"},{"key":"e_1_2_10_65_1","first-page":"70","article-title":"Phenotypic characterization of hepatic proliferation. Antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis, and nodular transformation of the liver","volume":"110","author":"Gerber MA","year":"1983","journal-title":"Am J Pathol"},{"key":"e_1_2_10_66_1","first-page":"673","article-title":"Differential cytokeratin and alpha\u2010fetoprotein expression in morphologically distinct epithelial cells emerging at the early stage of rat hepatocarcinogenesis","volume":"45","author":"Germain L","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_10_67_1","first-page":"368","article-title":"Promotion of growth and differentiation of rat ductular oval cells in primary culture","volume":"48","author":"Germain L","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_10_68_1","first-page":"317","article-title":"Morphologic identification by electronmicroscopy of oval cells in experimental hepatic degeneration","volume":"10","author":"Grisham JW","year":"1961","journal-title":"Lab Invest"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1980.tb29521.x"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67062236.x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00746-6"},{"key":"e_1_2_10_72_1","first-page":"699","article-title":"Identification of bipotential progenitor cells in human liver regeneration","volume":"75","author":"Haque S","year":"1996","journal-title":"Lab Invest"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01324802"},{"key":"e_1_2_10_74_1","first-page":"3750","article-title":"Monoclonal antibodies recognizing oval cells induced in the liver of rats by N\u20102\u2010fluorenylacetamide or ethionine in a choline\u2010deficient diet","volume":"45","author":"Hixson DC","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.300.5616.35a"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0963-6897(95)02019-5"},{"key":"e_1_2_10_77_1","first-page":"1823","article-title":"Expression of hepatocyte growth factor and c\u2010met genes during hepatic differentiation and liver development in the rat","volume":"142","author":"Hu Z","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-2-12-1230"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000205"},{"key":"e_1_2_10_80_1","first-page":"765","article-title":"Phenotypic modulation of perisinusoidal cells following acute liver injury: a quantitative analysis","volume":"73","author":"Johnson SJ","year":"1992","journal-title":"Int J Exp Pathol"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374748"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00386160"},{"key":"e_1_2_10_83_1","first-page":"449","article-title":"Cell\u2010type\u2010specific expression of neural cell adhesion molecule (N\u2010CAM) in Ito cells of rat liver. Up\u2010regulation during in vitro activation and in hepatic tissue repair","volume":"149","author":"Knittel T","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050421"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70407-5"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa3461002"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1076\/ejom.37.4.223.4724"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02933897"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-01-00014.1994"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/37.6.2723399"},{"key":"e_1_2_10_91_1","first-page":"535","article-title":"Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D\u2010galactosamine","volume":"139","author":"Lemire JM","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_10_92_1","first-page":"390","article-title":"Histogenesis of bile duct\u2010like cells proliferating during ethionine hepatocarcinogenesis: evidence for a biliary epithelial nature of oval cells","volume":"66","author":"Lenzi R","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70567-6"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290631"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH700>3.0.CO;2-5"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180100310"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084952102001258"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65299-6"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2002.tb00311.x"},{"key":"e_1_2_10_100_1","first-page":"526","article-title":"Co\u2010proliferation of \u201coval\u201d cells and fat storing cells\u2010myofibroblasts in rat liver during hepatocarcinogenesis: an immunohistochemical study","volume":"4","author":"Miyazaki H","year":"1993","journal-title":"Kupffer Cell Found"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.4.1431"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050524"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80269-8"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230634"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290232"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50371"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01360-3"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027469"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1155\/1993\/59691"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.42.153"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.80.3.231"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64082-5"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1989.tb14818.x"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5417.1168"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.22178"},{"key":"e_1_2_10_116_1","first-page":"165","article-title":"Expression of neuron\u2010specific enolase, chromogranin A, synaptophysin and Leu\u20107 in lung cancer cell lines","volume":"17","author":"Poola I","year":"1998","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-118-3-1200"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1993.tb00603.x"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0045(19970215)30:3<160::AID-PROS3>3.0.CO;2-Q"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.2741\/reeves"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80318-9"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240137"},{"key":"e_1_2_10_123_1","first-page":"1019","article-title":"Neuroendocrine features of reactive bile ductules in cholestatic liver disease","volume":"137","author":"Roskams T","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_10_124_1","first-page":"32","article-title":"Cells with neuroendocrine features in regenerating human liver","volume":"23","author":"Roskams T","year":"1991","journal-title":"APMIS"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb01178.x"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb01237.x"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210410"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.d01-438.x"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240310"},{"key":"e_1_2_10_130_1","first-page":"779","article-title":"Parathyroid\u2010hormone\u2010related peptides: a new class of multifunctional proteins","volume":"150","author":"Roskams T","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_10_131_1","first-page":"259","article-title":"Ductular reaction and its diagnostic significance","volume":"15","author":"Roskams T","year":"1998","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80065-2"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00333-7"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815564"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63489-X"},{"key":"e_1_2_10_136_1","first-page":"27","article-title":"Hepatic fibrosis: role of hepatic stellate cell activation","volume":"4","author":"Safadi R","year":"2002","journal-title":"MedGenMed"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb25421.x"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)80196-0"},{"key":"e_1_2_10_139_1","first-page":"1233","article-title":"Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers","volume":"138","author":"Schmitt\u2010Gr\u00e4ff A","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01120311"},{"key":"e_1_2_10_141_1","first-page":"298","article-title":"Chromogranin A, neuron\u2010specific enolase and synaptophysin as neuroendocrine cell markers in the diagnosis of tumours of the gastro\u2010entero\u2010pancreatic system","volume":"16","author":"Schurmann G","year":"1990","journal-title":"Eur J Surg Oncol"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80023-X"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1177\/41.6.8315280"},{"key":"e_1_2_10_144_1","first-page":"3811","article-title":"Is there a liver stem cell?","volume":"50","author":"Sell S","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270202"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-19-07326.2003"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195759"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2620001"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.17.7907"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.50.525"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3616618"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(88)80042-4"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300614"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310135"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.9124"},{"key":"e_1_2_10_156_1","first-page":"168","article-title":"Hepatocarcinomas, cholangiocarcinomas, and hepatoblastomas produced by chemically transformed cultured rat liver epithelial cells. A light\u2010 and electron\u2010microscopic analysis","volume":"127","author":"Tsao MS","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90011-3"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.161.157"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80061-X"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027468"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01539"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01531"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(88)90101-0"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03016.x"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890062"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700760213"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.035005454.x"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01544.x"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5820"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250213"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80043-9"},{"key":"e_1_2_10_172_1","first-page":"65","article-title":"Proliferation and differentiation of ductular progenitor cells and littoral cells during the regeneration of the rat liver to CCl4\/2\u2010AAF injury","volume":"17","author":"Yin L","year":"2002","journal-title":"Histol Histopathol"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040425"}],"container-title":["The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.a.20096","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.a.20096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:52:28Z","timestamp":1759971148000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.a.20096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,24]]},"references-count":172,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1002\/ar.a.20096"],"URL":"https:\/\/doi.org\/10.1002\/ar.a.20096","archive":["Portico"],"relation":{},"ISSN":["1552-4884","1552-4892"],"issn-type":[{"value":"1552-4884","type":"print"},{"value":"1552-4892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,24]]}}}