{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:49:42Z","timestamp":1778158182891,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technique, University of San Luis (CyT UNSL)","award":["Project 22Q\/303"],"award-info":[{"award-number":["Project 22Q\/303"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about morphological changes in the epididymis in relation to the natural photoperiod or their influence on sperm maturation. The viscacha is a seasonal rodent living in the Southern Hemisphere. The adult males exhibit an annual reproductive cycle with periods of maximum gonadal activity and gonadal regression. In this work, we studied seasonal variations in the morphology and cellular population of the epididymis during both periods, and we compared these results with those recorded at the testicular level. Epididymides were removed and studied by light microscopy. Measurements of luminal diameter, epithelial height, thickness of the lamina propria, and relative cellular distribution were performed. Analysis of variance (ANOVA) or nonparametric ANOVA was used to compare the results. Striking quantitative and qualitative changes were observed. Epididymides in periods of gonadal regression showed a significant decrease in luminal diameter and epithelial height in cauda, while the thickness of the lamina propria increased. In the epididymal corpus, the number of clear cells increased, and the cytoplasm of principal cells showed numerous giant vacuoles. During the active period, the number of halo cells increased and the cytoplasm of these cells was filled with dense bodies. In conclusion, the epididymis of the viscacha exhibits important seasonal morphological changes throughout annual reproductive cycle. The epididymal corpus and cauda segments appeared to be the segments most sensitive to seasonal cyclical variations of the external environment. We therefore postulate that the epididymal morphology of the viscacha probably could be regulated by the natural photoperiod. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.a.20144","type":"journal-article","created":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T14:48:53Z","timestamp":1101912533000},"page":"83-92","source":"Crossref","is-referenced-by-count":41,"title":["Epididymis of viscacha (<i>Lagostomus maximus maximus<\/i>): Morphological changes during the annual reproductive cycle"],"prefix":"10.1002","volume":"282A","author":[{"given":"Claudia","family":"Aguilera\u2010Merlo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Scardapane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Piezzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092090207"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD9930361"},{"key":"e_1_2_6_4_1","first-page":"7","article-title":"Ultrastructural study on the epithelium lining ducts epididymis in adult cats (Felis catus)","volume":"97","author":"Arrighi S","year":"1993","journal-title":"Arch Biol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401660210"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138416"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1997.19110077.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(19991201)256:4<335::AID-AR1>3.0.CO;2-I"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71471-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(80)90080-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1987.tb00858.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000212019"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001520409"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod45.3.493"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.1993.1068"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001900404"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001720205"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01256636"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/11.3.558"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.2460\/ajvr.1984.45.11.2380","article-title":"Age\u2010related changes in the cat testis and epididymis","volume":"45","author":"Hart L","year":"1984","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001830202"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1990.tb00186.x"},{"key":"e_1_2_6_23_1","first-page":"47","article-title":"A formaldhide\u2010glutaraldehyde fixative of high osmolarity for use in electron microscopy","volume":"11","author":"Karnovsky MJ","year":"1965","journal-title":"J Biophys Biochem Cytol"},{"key":"e_1_2_6_24_1","first-page":"289","article-title":"Ecolog\u00eda de la vizcacha (Lagostomus maximus maximus) en el nordeste de la provincia de Entre Rios","volume":"6","author":"Llanos AC","year":"1952","journal-title":"Revista Invest Agric Bs As"},{"key":"e_1_2_6_25_1","first-page":"1","article-title":"Animal photoperiodism","volume":"25","author":"Lofts B","year":"1975","journal-title":"Inst Biol Studies Biol"},{"key":"e_1_2_6_26_1","first-page":"23","article-title":"Seasonal variations and ultrastructure of colloid accumulation in the pituitary pars distalis of viscacha (L.m.m.)","volume":"18","author":"Mohamed F","year":"1994","journal-title":"Biocell"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-8166(97)80078-X"},{"key":"e_1_2_6_28_1","unstructured":"Mu\u00f1ozE.1998.Estudio estacional del compartimiento tubular e intersticial del test\u00edculo de vizcacha (Lagostomus maximus maximus): papel de la melatonina en la ciclicidad reproductiva y su relaci\u00f3n con el fotoper\u00edodo. Doctoral thesis. San Luis Argentina: Biblioteca Central de la UNSL."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199809)252:1<8::AID-AR2>3.0.CO;2-T"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(20010201)262:2<176::AID-AR1022>3.0.CO;2-I"},{"key":"e_1_2_6_31_1","first-page":"273","article-title":"Biological role of the pineal: responses to the environmental photoperiod","volume":"17","author":"Piezzi RS","year":"1984","journal-title":"Arch Biol Med Exp"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001490407"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1071\/ZO9570223"},{"key":"e_1_2_6_34_1","first-page":"999","volume-title":"The physiology of reproduction","author":"Robaire B","year":"1988"},{"key":"e_1_2_6_35_1","first-page":"183","article-title":"Effect of chronic administration of melatonin on viscacha pars intermedia (Lagostomus maximus maximus)","volume":"2","author":"Scardapane L","year":"1983","journal-title":"Comp Biol"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0264.2001.00338.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod58.2.497"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod61.3.705"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001540104"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091960304"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb27323.x"},{"key":"e_1_2_6_42_1","first-page":"21","article-title":"Histology of the epididymis in the human adult","volume":"8","author":"Vendrely E","year":"1981","journal-title":"Prog Reprod Biol"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00212221"}],"container-title":["The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.a.20144","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.a.20144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:49:53Z","timestamp":1759924193000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.a.20144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1002\/ar.a.20144"],"URL":"https:\/\/doi.org\/10.1002\/ar.a.20144","archive":["Portico"],"relation":{},"ISSN":["1552-4884","1552-4892"],"issn-type":[{"value":"1552-4884","type":"print"},{"value":"1552-4892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}