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To investigate this aspect of hyperhomocysteinemia, we analyzed the skeleton of CBS\u2010deficient mice, a murine model of severe hyperhomocysteinemia. Radiography, Alcian Blue\/Alizarin Red S\u2010stained whole skeletal preparations, and histological comparisons were used to determine the extent, pattern, and distribution of skeletal abnormalities in CBS\u2010deficient mice. Disruption of the murine CBS gene leads to skeletal abnormalities, notably kyphoscoliosis, with temporal shortening of long bones due to impaired cartilage differentiation, albeit to differing degrees. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.a.20145","type":"journal-article","created":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T14:48:58Z","timestamp":1101912538000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["Cystathionine \u03b2 synthase deficiency affects mouse endochondral 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