{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:14:51Z","timestamp":1791015291404,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T00:00:00Z","timestamp":1142812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cochlear implantation trauma and noise\u2010induced hearing loss both involve a physical disruption of the organ of Corti and may involve several mechanisms of cell death at the molecular level, i.e., necrosis, necrosis\u2010like programmed cell death (PCD; type 2 PCD), and apoptosis (type 1 PCD). This article reviews several promising therapeutic strategies that are currently being developed. One of these promising new strategies involves the use of a highly effective peptide inhibitor of the c\u2010Jun N\u2010terminal kinase cell death signal cascade (i.e., D\u2010JNKI\u20101) to prevent apoptosis of injured auditory hair cells. Our recent studies showed prevention of cochlear implantation\u2010induced hearing loss by infusing this peptide into the cochlea of guinea pigs. Another otoprotective therapy under investigation is the application of mild hypothermia to protect the cochlea from the development of a hearing loss that follows exposure to a physical trauma, e.g., electrode array insertional trauma. These forward\u2010looking strategies have the potential of improving hearing outcomes after cochlear implantation and providing novel means of otoprotection from noise\u2010induced trauma. Anat Rec Part A, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.a.20305","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T18:47:08Z","timestamp":1142880428000},"page":"473-481","source":"Crossref","is-referenced-by-count":90,"title":["Cochlear implantation trauma and noise\u2010induced hearing loss: Apoptosis and therapeutic strategies"],"prefix":"10.1002","volume":"288A","author":[{"given":"Adrien A.","family":"Eshraghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Van De Water","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480260000021"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000173169.45262.ae"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.1.77"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.127"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296740"},{"key":"e_1_2_6_7_1","first-page":"177","article-title":"Brain damage and temperature: cellular and molecular mechanisms","volume":"71","author":"Dietrich WD","year":"1996","journal-title":"Adv Neurol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ics.2004.08.025"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1179\/cim.2004.5.2.71","article-title":"Small fenestra cochleostomy for MED\u2010EL Flex electrode","volume":"5","author":"Eshraghi AA","year":"2004","journal-title":"Cochlear Implant Internat"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000169791.53201.e1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510043918"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110001004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(84)90111-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00097-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1139\/o05-065"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800760370774"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00286-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00361-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.08.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200107030-00041"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199601000-00012"},{"key":"e_1_2_6_23_1","first-page":"1","article-title":"Role of mitochondria as the gardens of cell death","volume":"21","author":"Kim R","year":"2005","journal-title":"Cancer Chemother Pharmacol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000914"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-002-3038-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-01-00043.2000"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200305000-00011"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200407000-00035"},{"key":"e_1_2_6_29_1","unstructured":"Van De WaterTR EshraghiAA HeJ et al.2005.Blocking of the MAPK\/JNK stress activated signal cascade prevents the progressive component of electrode trauma\u2010induced hearing loss. New Orleans LA: 28th Annual Meeting of the ARO. p16\u201317."},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-24-08596.2003"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199309000-00010"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.04.015"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00161-1"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19960801)45:3<282::AID-JNR10>3.0.CO;2-6"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568007043337166"}],"container-title":["The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.a.20305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.a.20305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:17:03Z","timestamp":1759951023000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.a.20305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,20]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1002\/ar.a.20305"],"URL":"https:\/\/doi.org\/10.1002\/ar.a.20305","archive":["Portico"],"relation":{},"ISSN":["1552-4884","1552-4892"],"issn-type":[{"value":"1552-4884","type":"print"},{"value":"1552-4892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,20]]}}}