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However, it has not been clarified whether the carotid body has the ability to perceive the stimulation of proinflammatory cytokines. Interleukin 6 (IL\u20106) as a multifunctional cytokine plays a pivotal role in host defense mechanism. In the present study, we observed the expression of IL\u20106R\u03b1 mRNA and protein in the carotid body using immunohistochemistry, Western blots, and in situ hybridization. The results confirmed the presence of IL\u20106R\u03b1 proteins and mRNAs in the glomus cells of rat carotid body. 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