{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:49:09Z","timestamp":1790520549942,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,4,10]],"date-time":"2002-04-10T00:00:00Z","timestamp":1018396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The larvae and adults of <jats:italic>Aedes aegypti<\/jats:italic> were tested for the potential to develop resistance to the synthetic pyrethroid, deltamethrin, alone or a combination of deltamethrin with the synergist, piperonyl butoxide (PBO). Although continuous larval selection for 40 generations resulted in 703\u2010fold resistance, the resistance ratio in the adults was only 1.3. Similarly, adult selections with deltamethrin showed a resistance ratio of less than four after 40 generations, indicating differential response to deltamethrin selection in the two developmental stages of the insect. When the susceptible larvae were subjected to selection pressure of deltamethrin and PBO in the ratio of 1:5 for 20 generations, the speed of selection for deltamethrin resistance slowed down by 60%. The F<jats:sub>24<\/jats:sub> larvae obtained from the strain selected with deltamethrin alone were further subjected to selection pressure with synergized deltamethrin, which resulted in 89% reversal in deltamethrin resistance in just one generation. However, long\u2010term selection with the insecticide\u2010synergist combination returned resistance close to original levels in 15 generations. The data indicate the involvement of cytochrome P<jats:sub>450<\/jats:sub>\u2010dependent detoxification as the primary mechanism of development of resistance to deltamethrin in the larvae. Implications of the results on the management of larval and adult stages of <jats:italic>Ae. aegypti<\/jats:italic> are discussed.Arch. Insect Biochem. Physiol. 50:1\u20138, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/arch.10021","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:21:03Z","timestamp":1030317663000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Effect of the synergist, piperonyl butoxide, on the development of deltamethrin resistance in yellow fever mosquito, <i>Aedes aegypti<\/i> L. (Diptera: Culicidae)"],"prefix":"10.1002","volume":"50","author":[{"given":"Sarita","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Sahgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.K.K.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/18.2.265a"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60171a013"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780150204"},{"key":"e_1_2_1_5_1","first-page":"53","article-title":"Pyrethroid cross resistance spectrum among populations of An. gambiae S. 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