{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:30:08Z","timestamp":1786977008826,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T00:00:00Z","timestamp":1110240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    THQ (1\u2010aroyl\u20104\u2010(arylamino)\u20101,2,3,4\u2010tetrahydroquinoline) compounds were identified by FMC Corporation in cell\u2010based assays that used ecdysone receptors from\n                    <jats:italic>Drosophila melanogaster, Heliothis virescens<\/jats:italic>\n                    , or\n                    <jats:italic>Plodia interpunctata<\/jats:italic>\n                    . THQ compounds showed weak insecticidal activity against\n                    <jats:italic>H. virescens<\/jats:italic>\n                    and, therefore, were not developed further. Several ecdysone agonists based on THQ chemotype have been synthesized and tested for their activity against a number of EcRs in transactivation assays. The THQ compound, RG\u2010120768, activated AaEcR (EcR from\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    ) but did not activate EcRs cloned from other insects. In transactivation assays, all six THQ ligands tested functioned through AaEcR but not through CfEcR (EcR from\n                    <jats:italic>Choristoneura fumiferana<\/jats:italic>\n                    ). Three THQ compounds that showed higher activity in transactivation assays were tested in tobacco bud moth,\n                    <jats:italic>H. virescens<\/jats:italic>\n                    , and yellow fever mosquito,\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    . These compounds showed higher activity in\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    when compared to their activity in\n                    <jats:italic>H. virescens<\/jats:italic>\n                    . These data show that the THQ ligands are a new class of non\u2010steroidal ecdysone agonists with preferential activity against mosquitoes. Arch. Insect Biochem. Physiol. 58:234\u2013242, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/arch.20046","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T10:46:51Z","timestamp":1110278811000},"page":"234-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Biochemical mode of action and differential activity of new ecdysone agonists against mosquitoes and moths"],"prefix":"10.1002","volume":"58","author":[{"given":"S. R.","family":"Palli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Tice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. M.","family":"Margam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80624-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02112"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1526-4998(200102)57:2<115::AID-PS245>3.0.CO;2-A"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0965-1748(94)00045-J"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00056-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.43.1.545"},{"key":"e_1_2_1_8_1","unstructured":"DixsonJA ElshenawyZM EldridgeJR DunganLB ChiuG WowkunGS WyleMJ.2000.A new class of potent ecdysone agonists: 4\u2010phenylamino\u20101 2 3 4\u2010tetrahydroquinolin.2000 May 15\u201317; The University of Delaware Newark DE."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0965-1748(95)00023-O"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(97)00075-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(97)00019-2"},{"key":"e_1_2_1_12_1","unstructured":"HillRJ.1999.Novel genetic sequences encoding steroid and juvenile hormone receptor polypeptides and insecticidal modalities therefore. 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