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Current strategies to control\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    rely heavily on insecticide interventions. Pyrethroids are a major class of insecticides used for mosquito control because of their fast acting, highly insecticidal activities and low mammalian toxicity. However,\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    populations around the world have begun to develop resistance to pyrethroids. So far, more than a dozen mutations in the sodium channel gene have been reported to be associated with pyrethroid resistance in\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    . Co\u2010occurrence of resistance\u2010associated mutations is common in pyrethroid\u2010resistant\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    populations. As global use of pyrethroids in mosquito control continues, new pyrethroid\u2010resistant mutations keep emerging. In this microreview, we compile pyrethroid resistance\u2010associated mutations in\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    in a chronological order, as they were reported, and summarize findings from functional evaluation of these mutations in an in vitro sodium channel expression system. We hope that the information will be useful for tracing possible evolution of pyrethroid resistance in this important human disease vector, in addition to the development of methods for global monitoring and management of pyrethroid resistance in\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/arch.21686","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T23:30:07Z","timestamp":1588807807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Chronology of sodium channel mutations associated with pyrethroid resistance in\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1002","volume":"104","author":[{"given":"Mengli","family":"Chen","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of life sciences China Jiliang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhe","family":"Du","sequence":"additional","affiliation":[{"name":"Biological Control of Pest Research Unit USDA\u2010ARS Stoneville Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Entomology, Genetics and Neuroscience Programs Michigan State University East Lansing Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris S.","family":"Zhorov","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences McMaster University Hamilton Ontario Canada"},{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-6350","authenticated-orcid":false,"given":"Ke","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Entomology, Genetics and Neuroscience Programs Michigan State University East Lansing Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-46702015000100003"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2089-5"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbe.2015.11.009"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2096-6"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3846"},{"issue":"4","key":"e_1_2_4_7_1","first-page":"953","article-title":"V1016G point mutation: The key mutation in the voltage\u2010gated sodium channel (Vgsc) gene of pyrethroid\u2010resistant Aedes aegypti (Diptera: Culicidae) in Indonesia","volume":"56","author":"Amelia\u2010Yap Z. 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