{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:02:54Z","timestamp":1753862574821,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Weifang University Doctor Startup Fund","award":["2020BS26"],"award-info":[{"award-number":["2020BS26"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, glutathione\u2010S\u2010transferase pull\u2010down combined with mass spectrometry techniques were used to identify the candidate proteins interacting with protein tyrosine phosphatase of the\u00a0<jats:italic>Bombyx Mori<\/jats:italic> nucleopolyhedrovirus in the\u00a0<jats:italic>B. mori<\/jats:italic> (BmNPV\u2010PTP) brain. A total of 36 proteins were identified from BmNPV\u2010PTP coprecipitate samples by searching the NCBI_<jats:italic>Bombyx Mori<\/jats:italic> database with the original mass spectrum data. Among those proteins, the interaction between BmNPV\u2010PTP and <jats:italic>B. mori<\/jats:italic> cyclophilin A may accelerate\u00a0the apoptosis of certain nerve cells involved\u00a0in regulating behavior, and thus may be an inducer of enhanced locomotor activity (ELA). After the BmNPV invasion, BmNPV\u2010PTP binding to peripheral\u2010type benzodiazepine receptors may initiate a series of abnormal cascades of the nervous system, which results\u00a0in abnormal hyperactive behavior in <jats:italic>B. mori<\/jats:italic>. Besides this, vacuolar ATP synthase catalytic subunit A, annexin, and several enzymes for energy conversion were identified, which may play a role\u00a0in enhancing viral entry and infectivity and provide energy for enhancing the locomotor activity of <jats:italic>B. mori<\/jats:italic>. In general, the results of this study will facilitate the understanding of the molecular mechanisms underlying the ELA of <jats:italic>B. mori<\/jats:italic> larva induced by BmNPV.<\/jats:p>","DOI":"10.1002\/arch.21732","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T05:30:41Z","timestamp":1597210241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Screening of <i>Bombyx mori<\/i> brain proteins interacting with protein tyrosine phosphatase of BmNPV"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7258-6317","authenticated-orcid":false,"given":"Guobao","family":"Wang","sequence":"first","affiliation":[{"name":"College of Biological and Agricultural Engineering Weifang University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Na","sequence":"additional","affiliation":[{"name":"College 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