{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:25:38Z","timestamp":1770974738778,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuropeptides control many physiological and behavioral processes, and so they are functionally important classes of cell\u2010to\u2010cell signaling molecules. Nowadays, the fall armyworm, <jats:italic>Spodoptera frugiperda<\/jats:italic>, is one of the most destructive agricultural pests in the world. In this study, we mined the publicly accessible genome assembly data for <jats:italic>S. frugiperda<\/jats:italic>, and the transcriptomic and proteomic data of the larval central nervous system (CNS) for putative neuropeptide\u2010encoding, and subsequently we used these to anticipate a peptidome for this species. In essence, we could identify 57 orthologs of insect neuropeptides, including Allatotropin, CCHamide, Corazonin, pheromone biosynthesis activating neuropeptide, short neuropeptide F, Trissin, and Natalisin. Interesting features for <jats:italic>S. frugiperda<\/jats:italic> were the absence of genes coding for CNMamide, Elevein, and the differential evolution of ancestral neuropeptide genes such as adipokinetic corazonin\u2010related peptide, adipokinetic hormone, Tachykinin, and Natalisin. In conclusion, our study provides the most complete neuropeptide description for the important pest <jats:italic>S. frugiperda<\/jats:italic> as a foundation to study the factors regulating insect growth, reproduction, and behavior. Second, we confirm that a comprehensive multi\u2010omics analysis is necessary for the identification of neuropeptides. Finally, our data provide a reliable reference for other comparative studies in other insects beyond the supermodel insect of <jats:italic>Drosophila melanogaster<\/jats:italic> and the finding of potential candidates as selective for pests versus beneficial insects.<\/jats:p>","DOI":"10.1002\/arch.21740","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T06:38:21Z","timestamp":1601966301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genomics, transcriptomics, and peptidomics of <i>Spodoptera frugiperda<\/i> (Lepidoptera, Noctuidae) neuropeptides"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-2064","authenticated-orcid":false,"given":"Yan","family":"Shi","sequence":"first","affiliation":[{"name":"Key Lab of Integrated Crop Pest Management of Shandong Province,\u00a0College\u00a0of\u00a0Plant\u00a0Health\u00a0and\u00a0Medicine Qingdao Agricultural University Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiangJie","family":"Li","sequence":"additional","affiliation":[{"name":"Key Lab of Integrated Crop Pest Management of Shandong Province,\u00a0College\u00a0of\u00a0Plant\u00a0Health\u00a0and\u00a0Medicine Qingdao Agricultural University Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LinYu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Lab of Integrated Crop Pest Management of Shandong Province,\u00a0College\u00a0of\u00a0Plant\u00a0Health\u00a0and\u00a0Medicine Qingdao Agricultural University Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GanLin","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Lab of Integrated Crop Pest Management of Shandong Province,\u00a0College\u00a0of\u00a0Plant\u00a0Health\u00a0and\u00a0Medicine Qingdao Agricultural University Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir M.","family":"Bilal","sequence":"additional","affiliation":[{"name":"Key Lab of Integrated Crop Pest Management of Shandong Province,\u00a0College\u00a0of\u00a0Plant\u00a0Health\u00a0and\u00a0Medicine Qingdao Agricultural University Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Smagghe","sequence":"additional","affiliation":[{"name":"Department of Plants and Crops, Faculty of Bioscience Engineering Ghent University Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong\u2010Xian","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Lab of Integrated Crop Pest Management of Shandong Province,\u00a0College\u00a0of\u00a0Plant\u00a0Health\u00a0and\u00a0Medicine Qingdao Agricultural University Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-3223-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0282(2001)60:6<460::AID-BIP10181>3.0.CO;2-Y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-017-0314-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-394389-7.00001-6","article-title":"Water homeostasis and osmoregulation as targets in the control of insect pests","volume":"44","author":"Cohen E.","year":"2013","journal-title":"Advances in Insect Physiology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.849004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.21587"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10461-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.10.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.084"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.045369"},{"key":"e_1_2_8_12_1","first-page":"979","article-title":"Effect of rearing temperature and humidity on fecundity and fertility of silkworm, Bombyx mori L. 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