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The present study has been conducted to investigate the influence of melatonin (0.025\u2009mM) on behavioral responses of <jats:italic>lgl<\/jats:italic> mutant flies as well as on biochemical indices (redox homeostasis, carbohydrate and lipid metabolism, transaminases, and minerals) in hemolymph, and head and intestinal tissues. Behavioral abnormalities were quantitatively observed in <jats:italic>lgl<\/jats:italic> flies but were found normalized among melatonin\u2010treated <jats:italic>lgl<\/jats:italic> flies. Significantly decreased levels of lipid peroxidation products and antioxidants involved in redox homeostasis were observed in hemolymph and tissues of <jats:italic>lgl<\/jats:italic> flies, but had restored close to normalcy in melatonin\u2010treated flies. Carbohydrates including glucose, trehalose, and glycogen were decreased and increased in the hemolymph and tissues of <jats:italic>lgl<\/jats:italic> and melatonin\u2010treated <jats:italic>lgl<\/jats:italic> flies, respectively. Key enzymes of carbohydrate metabolism showed a significant increment in their levels in <jats:italic>lgl<\/jats:italic> mutants but had restored close to wild\u2010type baseline levels in melatonin\u2010treated flies. Variables of lipid metabolism showed significantly inverse levels in hemolymph and tissues of <jats:italic>lgl<\/jats:italic> flies, while normalization of most of these variables was observed in melatonin\u2010treated mutants. Lipase, chitinase, transaminases, and alkaline phosphatase showed an increment in their activities and minerals exhibited decrement in <jats:italic>lgl<\/jats:italic> flies; reversal of changes was observed under melatonin treatment. The impairment of cognition, disturbance of redox homeostasis and metabolic reprogramming in <jats:italic>lgl<\/jats:italic> flies, and restoration of normalcy in all these cellular and behavioral processes indicate that melatonin could act as oncostatic and cytoprotective agents in <jats:italic>Drosophila<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/arch.21785","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T12:21:55Z","timestamp":1617625315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Melatonin improves cognitive behavior, oxidative stress, and metabolism in tumor\u2010prone <i>lethal giant larvae<\/i> mutant of <i>Drosophila melanogaster<\/i>"],"prefix":"10.1002","volume":"107","author":[{"given":"Kar\u2010Cheng","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srivani","family":"Sankaran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University Chidambaram Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6708-1800","authenticated-orcid":false,"given":"Jaime J.","family":"Jayapalan","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"},{"name":"University of Malaya Centre for Proteomics Research (UMCPR) University of Malaya Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perumal","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University Chidambaram Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puteri S.","family":"Abdul\u2010Rahman","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"},{"name":"University of Malaya Centre for Proteomics Research (UMCPR) University of Malaya Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2016.02.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24220"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.06.034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2019.09.011"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.10.052"},{"key":"e_1_2_10_7_1","first-page":"79","article-title":"Electrolyte disorders in cancer patients: A systematic review","volume":"5","author":"Berardi R.","year":"2019","journal-title":"Journal of Cancer Metastasis and Treatment"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1211604"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2020.104063"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12597"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24420"},{"key":"e_1_2_10_13_1","first-page":"277939","article-title":"Tumor cell\u2013adipocyte gap junctions activate lipolysis and are essential for breast tumorigenesis","author":"Camarda R.","year":"2018","journal-title":"bioRxiv"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.4055"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.039180"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1999.tb00610.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600200"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2019.07.003"},{"key":"e_1_2_10_19_1","first-page":"69","article-title":"A review of biological and pharmacological actions of melatonin: Oxidant and prooxidant properties","volume":"4","author":"Eghbal M. 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