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The hearing organ of <jats:italic>Drosophila<\/jats:italic> (Johnston's organ [JO]) shares much structural, developmental, and functional similarity with the vertebrate hearing organ (Organ of Corti). JO is evolving as a potential model system to examine the hearing\u2010associated defects in vertebrates. In the vertebrates, aminoglycosides like gentamicin, kanamycin, and neomycin have been known to cause defects in the hearing organ. However, a complete mechanism of toxicity is not known. Taking the evolutionary conservation into account the current study aims to test various concentrations of aminoglycoside on the model organism, <jats:italic>Drosophila melanogaster<\/jats:italic>. The current study uses the oral route to check the toxicity of various aminoglycosides at different concentrations (50, 100, 150, 200, and 250\u2009\u03bcg\u2009ml<jats:sup>\u2212<\/jats:sup><jats:sup>1<\/jats:sup>). In <jats:italic>Drosophila<\/jats:italic>, many foreign particles enter the body through the gut via food. The aminoglycoside treated third instar larvae show defective crawling and sound avoidance behavior. The adult flies release lower amounts of acetylcholine esterase and higher amounts of reactive oxygen species than control untreated animals, accompanied by defective climbing and aggressive behavior. All these behavioral defects are further confirmed by the altered expression level of hearing genes such as <jats:italic>nompC<\/jats:italic>, <jats:italic>inactive<\/jats:italic>, <jats:italic>nanchung, pyrexia<\/jats:italic>. All the behavioral and genetic defects are reported as a readout of aminoglycoside toxicity.<\/jats:p>","DOI":"10.1002\/arch.21871","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T15:55:03Z","timestamp":1644681303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aminoglycoside treatment alters hearing\u2010related genes and depicts behavioral defects in <i>Drosophila<\/i>"],"prefix":"10.1002","volume":"110","author":[{"given":"Gyanaseni","family":"Dhar","sequence":"first","affiliation":[{"name":"Department of Life Science, Neural Developmental Biology Lab National Institute of Technology, Rourkela  Rourkela Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev K.","family":"Paikra","sequence":"additional","affiliation":[{"name":"Department of Life Science, Neural Developmental Biology Lab National Institute of Technology, Rourkela  Rourkela 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