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Most research has focused on proteins with SVWC domain that are induced after virus infection and are hypothesized to function as \u201ccytokines\u201d to regulate the innate immune response. The expansion of <jats:italic>SVWC<\/jats:italic> genes in insect species indicates that many other functions remain to be discovered. Research in shrimp has elucidated the adaptability of Vago\u2010like peptides in the innate immune response against bacteria, fungi and viruses after activation by Jak\u2010STAT and\/or Toll\/Imd pathways in which they can act as pathogen\u2010recognition receptors or cytokine\u2010like signaling molecules. SVWC factors also appear in scorpion venoms and tick saliva, underlining their versatility to acquire new functions. This review discusses the discovery and function of SVWC peptides from insects to crustaceans and chelicerates and reveals the enormous gaps in knowledge that remain to be filled to understand this enigmatic group of secreted peptides.<\/jats:p>","DOI":"10.1002\/arch.22071","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T14:30:05Z","timestamp":1704724205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Single domain von Willebrand factor type C \u201ccytokines\u201d and the regulation of the stress\/immune response in insects"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-6617","authenticated-orcid":false,"given":"Vassiliki","family":"Labropoulou","sequence":"first","affiliation":[{"name":"Insect Molecular Genetics and Biotechnology Institute of Biosciences &amp; Applications Athens 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