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In this study, we identified a UFL1 ortholog in <jats:italic>Bombyx mori<\/jats:italic> genome. Spatio\u2010temporal expression profiles showed that BmUFL1 expression was high in the midgut, epidermis, and testis and in the pupa\u2013adult stage. BmUFL1 knockdown inhibited <jats:italic>B. mori<\/jats:italic> nucleopolyhedrovirus (BmNPV)\u00a0proliferation, while BmUFL1 overexpression promoted BmNPV proliferation. Mechanically, protein kinase RNA\u2010like endoplasmic reticulum kinase (PERK) signaling and cell apoptosis are involved in BmUFL1\u2010regulated\u00a0BmNPV proliferation. Overall, these results suggest that BmUFL1 facilitates BmNPV proliferation in silkworm.<\/jats:p>","DOI":"10.1002\/arch.22127","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T18:21:15Z","timestamp":1720462875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Bombyx mori<\/i> UFL1 facilitates BmNPV proliferation by regulating host cell apoptosis through PERK"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6431-9976","authenticated-orcid":false,"given":"Yijun","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1223-8411","authenticated-orcid":false,"given":"Haonan","family":"Meng","sequence":"additional","affiliation":[{"name":"Anhui 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