{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:24:29Z","timestamp":1777375469422,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Histone acetylation levels maintained by histone acetyltransferases (HATs) and histone deacetylases play important roles in maintaining local chromatin accessibility and expression of genes that regulate many biological processes, including development and reproduction. N\u2010terminal acetylation of proteins catalyzed by N\u2010terminal acetyltransferases (NATs) also regulates gene expression. We identified 25 HATs\/NATs genes in the yellow fever mosquito, <jats:italic>Aedes aegypti<\/jats:italic>, and investigated their function in female reproduction using RNA interference (RNAi). Among the HATs\/NATs studied, the knockdown of AANAT1 (Arylamine N\u2010acetyltransferase), NAA40 (N\u2010alpha\u2010acetyltransferase 40), NAA80 (N\u2010alpha\u2010acetyltransferase 80), KAT7 (Histone lysine acetyltransferase 7), ACNAT (Acyl\u2010CoA N\u2010acyltransferase), and MCM3AP (Minichromosome maintenance complex component 3 associated protein) significantly reduced egg laying and caused severe problems in oocyte development compared to that in control insects injected with dsGFP. Gene expression analysis using RT\u2010qPCR revealed that vitellogenin and its receptor genes are downregulated in mosquitoes injected with dsAANAT1, dsNAA40, dsNAA80, dsKAT7, dsACNAT, and dsMCM3AP compared to that in control animals. Also, the knockdown of HATs\/NATs genes ATAT1 (Alpha\u2010tubulin N\u2010acetyltransferase 1), AANAT1, TAFIID (Transcription initiation factor TFIID subunit 1), HATB (Histone acetyltransferase type B) and NAT9 (N\u2010acetyltransferase 9) decreased more than 50% egg hatch by blocking embryonic development. These results suggest that the acetylation of proteins, especially histones mediated by NATs and HATs, plays an important role in regulating female reproduction and embryonic development of <jats:italic>Ae. aegypti<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/arch.70055","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T07:51:43Z","timestamp":1744789903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of Histone and N\u2010Terminal Acetyltransferases Required for Reproduction and Embryonic Development of Yellow Fever Mosquito, <i>Aedes aegypti<\/i>"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-4395","authenticated-orcid":false,"given":"Sundararajan","family":"Balasubramani","sequence":"first","affiliation":[{"name":"Department of Entomology Martin\u2010Gatton College of Food, Agriculture and Environment University of 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