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There has been growing interest in plant\u2010based repellents that display bioactive compounds with insecticidal and repellent activities. In this review, the focus is on a natural monoterpene that has gained therapeutic properties, including antifungal, antibacterial, antioxidant, anticancer, and neuropharmacological activity, including anti\u2010anxiety and sedative activity. The efficacy of linalool was assayed against mosquitoes in larvicidal and repellent bioassays. Larvicidal assays exhibited dose\u2010dependent mortality: 82% at 1%, 87.4% at 2%, and 90.8% at 4% concentration after 24\u2009h. Repellency cage assays exhibited good initial efficacy, with 1% linalool repelling 82.2% of mosquitoes, 2% repelling 81.8%, and 4% repelling 90.8%, very close to DEET's (N,N\u2010diethyl\u2010meta\u2010toluamide) 93.4%. After 210\u2009min, the 4% concentration had 82.2% repellency, while DEET had 89.6%. Tunnel tests revealed 4% linalool provided 90.2% repellency at 1\u2009h and 84% at 3\u2009h. The findings show that linalool, especially at high levels, is extremely effective as a repellent and larvicide. Its activity is as effective as that of DEET, the present synthetic repellent, and hence linalool can be utilized as an effective natural substitute for long\u2010lasting mosquito control.<\/jats:p>","DOI":"10.1002\/arch.70098","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T08:00:33Z","timestamp":1758528033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bioactivity of Linalool Against <i>Culex quinquefasciatus<\/i>: Repellent and Larvicidal Evaluations"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6489-1715","authenticated-orcid":false,"given":"Rajesh","family":"Kumar","sequence":"first","affiliation":[{"name":"University Institute of Pharma Sciences Chandigarh University Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-3479","authenticated-orcid":false,"given":"Payal","family":"Mittal","sequence":"additional","affiliation":[{"name":"University Institute of Pharma Sciences Chandigarh University Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-0264","authenticated-orcid":false,"given":"Monika","family":"Airi","sequence":"additional","affiliation":[{"name":"Department of Zoology Sri Guru Granth Sahib World University Fatehgarh Sahib Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6726622"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-9456-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2021.04.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2011-1090.ch001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-021-01261-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2024.2357624"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814043-7.00015-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011699"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2024.107324"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.22038\/AJP.2021.55681.2786"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects8010021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.30684\/etj.36.1b.11"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.04.023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aspen.2018.12.024"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13080691"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16071134"},{"issue":"5","key":"e_1_2_8_18_1","first-page":"73","article-title":"Mosquito Management: A Review","volume":"4","author":"Naseem S.","year":"2016","journal-title":"Journal of Entomology and Zoology Studies"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5376\/jmr.2016.06.0025)"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9010032"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.50.071803.130439"},{"issue":"7","key":"e_1_2_8_22_1","first-page":"533","article-title":"Diversity of Mosquito in India: Status Report","volume":"10","author":"Singh V.","year":"2023","journal-title":"Journal of Emerging Technologies and Innovative Research"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-023-05997-6"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"50","article-title":"A Catalogue of Indian Mosquitoes","volume":"2","author":"Tyagi B. 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