{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:53:33Z","timestamp":1774569213848,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Histone acetylation and deacetylation are essential for chromatin modifications that regulate various cellular functions. This study identified nine histone deacetylase (HDAC) genes in the yellow fever mosquito,\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , and investigated their roles in female reproduction and embryonic development using RNA interference (RNAi). RNAi\u2010mediated knockdown of HDAC1 (Histone deacetylase 1), HDAC3 (Histone deacetylase 3), HDAC4 (Histone deacetylase 4), and SIRT2 (Sirtuin 2) resulted in severe defects in oocyte development and reduced egg\u2010laying compared with control insects injected with double\u2010stranded RNA (dsRNA) targeting the green fluorescent protein gene (dsGFP). RT\u2010qPCR analysis showed that vitellogenin and its receptor genes are downregulated, leading to suppressed oocyte maturation in mosquitoes injected with dsRNAs targeting HDAC1, HDAC3, HDAC4, and SIRT2 compared with controls. Furthermore, knockdown of HDAC3, HDAC6, and HDAC8 inhibited embryonic development, resulting in reduced hatch rates. These results suggest that HDACs play a vital role in reproduction and embryonic development in\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/arch.70139","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:44:18Z","timestamp":1773027858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone Deacetylases Are Required for\n                    <i>Aedes aegypti<\/i>\n                    Female Reproduction and Embryonic Development"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-4395","authenticated-orcid":false,"given":"Sundararajan","family":"Balasubramani","sequence":"first","affiliation":[{"name":"Department of Entomology, Martin\u2010Gatton College of Agriculture Food and Environment University of Kentucky Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-3247","authenticated-orcid":false,"given":"Subba Reddy","family":"Palli","sequence":"additional","affiliation":[{"name":"Department of Entomology, Martin\u2010Gatton College of Agriculture Food and Environment University of Kentucky Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.70055"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2016.03.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.7.2170-2181.2002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2005.07.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083903"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.606392"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511945200"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2118871119"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2020.194576"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2024.104256"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00137"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909554116"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00683"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.10.11599"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.32"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-008-0261-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi201021h"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2023.103985"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.117.041541"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects11050265"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.11.2672"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.153353"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"668","article-title":"Transcriptome\u2010Based Analysis Reveals Chromatin Remodeling in Post\u2010Adult Eclosion Reconstruction of the Insect Fat Body","volume":"24","author":"Li Y.","year":"2025","journal-title":"Journal of Integrative Agriculture"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040438"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118403109"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2010.05.008"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0692-z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1563807"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2006.08.002"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2017.1325975"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf660"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.028"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000809"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2016.06.012"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-4373-3"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-020117-043258"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2016.05.004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720673115"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-021-01157-3"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19667-6"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2346"},{"key":"e_1_2_8_45_1","doi-asserted-by":"crossref","unstructured":"Zhang JinLi Z. J. Y. X.Yuan XiaoBo C. S.Chen SunJie et al. The Histone Deacetylase NlHDAC1 Regulates Both Female and Male Fertility in the Brown Planthopper Nilaparvata Lugens. 2018.","DOI":"10.1098\/rsob.180158"}],"container-title":["Archives of Insect Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/arch.70139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/arch.70139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/arch.70139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:08:13Z","timestamp":1774566493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/arch.70139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/arch.70139"],"URL":"https:\/\/doi.org\/10.1002\/arch.70139","archive":["Portico"],"relation":{},"ISSN":["0739-4462","1520-6327"],"issn-type":[{"value":"0739-4462","type":"print"},{"value":"1520-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70139"}}