{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:03Z","timestamp":1786977063506,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["CAAS\u2010ASTIP \u20102025\u2010IAR"],"award-info":[{"award-number":["CAAS\u2010ASTIP \u20102025\u2010IAR"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neonicotinoid imidacloprid is an environmentally contaminant that poses a high toxicity to non\u2010target organisms, honey bees (\n                    <jats:italic>Apis mellifera<\/jats:italic>\n                    ). Newly emerged bees are critical for colony resilience but vulnerable. This study evaluated the potential of phytochemical resveratrol in mitigating the toxicity induced by imidacloprid in newly emerged bees. To simulate a combined\u2010stress scenario, bees were exposed to imidacloprid at a concentration (0.25\u2009mg\/L) that represents elevated field residues. Newly emerged bees were administered a diet supplemented with resveratrol. A series of assays were conducted to evaluate survival rate, physiological indices, histomorphological alterations, enzyme activities, and transcriptomic profiles. The results demonstrated that dietary supplementation with resveratrol (0.6\u2009mg\/L resveratrol and 0.25\u2009mg\/L imidacloprid) exhibited significantly higher survival rates and improved food utilization efficiency compared to bees exposed to imidacloprid alone. Resveratrol mitigated imidacloprid\u2010induced midgut injury, aberrant sucrose enzyme activity, and restored homeostasis of genes involved in energy and nutrient metabolism (e.g. ATP synthesis, lipid, carbohydrate, and tyrosine metabolism), which were dysregulated by imidacloprid. Resveratrol alleviated oxidative stress via modulated CAT\/GST activity and normalized MDA level, and upregulated genes in phase I and II detoxification pathways (e.g.\n                    <jats:italic>GST<\/jats:italic>\n                    ,\n                    <jats:italic>UGTs<\/jats:italic>\n                    ,\n                    <jats:italic>P450<\/jats:italic>\n                    ). Notably, resveratrol attenuated imidacloprid\u2010induced brain injury and alleviated neurotoxicity by preserving cholinergic integrity and modulating gene expression associated with neural signaling pathway (e.g. AChE activity and the expression of\n                    <jats:italic>nAChR<\/jats:italic>\n                    and\n                    <jats:italic>GABA<\/jats:italic>\n                    receptor genes). The present work suggested the protective effects of resveratrol on the newly emerged bees in agroecosystems contaminated with neonicotinoid and provided a promising practical strategy.\n                  <\/jats:p>","DOI":"10.1002\/arch.70154","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:55:41Z","timestamp":1775670941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resveratrol Mitigates Imidacloprid\u2010Induced Neurotoxicity, Intestinal Dysfunction and Other Stresses in Newly Emerged Bees (\n                    <i>Apis mellifera<\/i>\n                    )"],"prefix":"10.1002","volume":"121","author":[{"given":"Jiali","family":"Hao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Resource Insects Institute of Apicultural Research, Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensu","family":"Han","sequence":"additional","affiliation":[{"name":"Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-8965","authenticated-orcid":false,"given":"Fen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) Hainan University Sanya China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects Institute of Apicultural Research, Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects Institute of Apicultural Research, Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects Institute of Apicultural Research, Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects Institute of Apicultural Research, Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingli","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects Institute of Apicultural Research, Chinese Academy of Agricultural Sciences Beijing 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