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Here, we investigated the role of EGFR in the reproductive development of the parasitoid wasp\n                    <jats:italic>Leptopilina drosophilae<\/jats:italic>\n                    , an effective natural enemy of the globally invasive pest\n                    <jats:italic>Drosophila suzukii<\/jats:italic>\n                    . We cloned the\n                    <jats:italic>LdEGFR<\/jats:italic>\n                    gene and confirmed its structural conservation through phylogenetic analysis. Using RNA interference (RNAi), we demonstrated that LdEGFR is essential for ovarian development but dispensable for testis development. Intriguingly, this sexually dimorphic functional requirement contrasts with its expression pattern, as\n                    <jats:italic>LdEGFR<\/jats:italic>\n                    transcript levels were approximately 171\u2010fold higher in testes than in ovaries. Transcriptomic analysis of ovaries following\n                    <jats:italic>LdEGFR<\/jats:italic>\n                    knockdown revealed significant down\u2010regulation of genes involved in transporter, DNA replication, cell cycle, and oocyte meiosis pathways, providing a molecular basis for the observed ovarian defects. Our findings establish LdEGFR as a critical regulator of female reproduction in\n                    <jats:italic>L. drosophilae<\/jats:italic>\n                    and highlight a notable decoupling between transcript abundance and functional essentiality. This study not only advances the understanding of reproductive regulation in parasitoid wasps but also identifies LdEGFR as a potential target for enhancing the mass rearing of this promising biocontrol agent.\n                  <\/jats:p>","DOI":"10.1002\/arch.70190","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:33:32Z","timestamp":1783532012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["EGFR Is Essential for Ovary but Not Testis Development in the Parasitoid Wasp\n                    <i>Leptopilina drosophilae<\/i>"],"prefix":"10.1002","volume":"122","author":[{"given":"Jieyu","family":"Shan","sequence":"first","affiliation":[{"name":"Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Insect Sciences, College of Agriculture and Biotechnology Zhejiang University Hangzhou China"},{"name":"Ministry of Agriculture 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