{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:58:24Z","timestamp":1790427504628,"version":"4.1.0"},"reference-count":118,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071510"],"award-info":[{"award-number":["32071510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei province","doi-asserted-by":"publisher","award":["C2025205003"],"award-info":[{"award-number":["C2025205003"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                    is a highly evolved extracellular pathogen that employs diverse strategies to persist within a complex enzootic cycle. As the causative agent of Lyme disease (LD), it has been the focus of extensive research into host\u2013pathogen interactions, particularly its mechanisms of survival in reservoir hosts and transmission dynamics, significantly advancing the field of tick\u2010borne diseases. This review summarized the discovery and development of\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    , and contributed towards a holistic view on the transmission dynamics and pathogenic mechanisms, with emphasis on the complement evasion mechanisms of\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    , which informed the current prevention efforts. Looking forward, the application of single\u2010cell high\u2010throughput sequencing is expected to elucidate novel molecular mechanisms underlying the transmission, and artificial intelligence technology holds promise for developing global tick\u2010borne disease databases and public communication platforms to support future prevention strategies. Overall, this review provides an integrated framework that bridges molecular pathogenesis, ecological dynamics, and technological innovation to inform both fundamental research and public health responses to LD.\n                  <\/jats:p>","DOI":"10.1002\/arch.70219","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:25:55Z","timestamp":1789842355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Biology, Ecology, and Pathogenesis of\n                    <i>Borrelia burgdorferi<\/i>\n                    Sensu Lato: Implications for Tick\u2010Borne Disease and Prevention"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1068-8008","authenticated-orcid":false,"given":"Han","family":"Wang","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Key Laboratory of Animal 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