{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:58:25Z","timestamp":1790427505982,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Heavy metals are transported and accumulated along the food chain, exposing phytophagous insects to high risks of contamination. This study investigated the mechanisms underlying Pb and Cd tolerance in\n                    <jats:italic>Lymantria dispar<\/jats:italic>\n                    by focusing on the ABC transporter family. Multiple ABC genes in the larval midgut were significantly upregulated under Pb and Cd stress, respectively. Among them,\n                    <jats:italic>LdABC7<\/jats:italic>\n                    showed the most prominent positive response to Pb stress, and\n                    <jats:italic>LdABC12<\/jats:italic>\n                    to Cd stress. Following silencing of\n                    <jats:italic>LdABC7<\/jats:italic>\n                    or\n                    <jats:italic>LdABC12<\/jats:italic>\n                    , larval growth inhibition under heavy metal stress was significantly exacerbated and the expression of apoptosis\u2010related genes was markedly up\u2010regulated. Genes associated with the mitochondrial pathway shifted further toward pro\u2010apoptosis after silencing of either\n                    <jats:italic>LdABC7<\/jats:italic>\n                    or\n                    <jats:italic>LdABC12<\/jats:italic>\n                    . At the cellular level, both LdABC7 and LdABC12 proteins were localized to the cell membrane.\n                    <jats:italic>Sf9<\/jats:italic>\n                    cells overexpressing these genes exhibited significantly increased cell viability, reduced apoptosis rates, restored mitochondrial membrane potential, reduced opening of the mitochondrial permeability transition pore (MPTP), and decreased levels of reactive oxygen species and calcium ions under heavy metal stress. Taken together,\n                    <jats:italic>LdABC7<\/jats:italic>\n                    and\n                    <jats:italic>LdABC12<\/jats:italic>\n                    serve as key detoxification components in\n                    <jats:italic>L. dispar<\/jats:italic>\n                    larvae in response to Pb and Cd stress, respectively, with the ability to maintain mitochondrial homeostasis and inhibit apoptosis.\n                  <\/jats:p>","DOI":"10.1002\/arch.70222","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:34:07Z","timestamp":1790343247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heavy Metal Tolerance in\n                    <i>Lymantria dispar<\/i>\n                    Larvae: Essential Roles of ABC Transporters in Resisting Heavy Metal Toxicity"],"prefix":"10.1002","volume":"123","author":[{"given":"Heyang","family":"Sun","sequence":"first","affiliation":[{"name":"School of Forestry Northeast Forestry University Harbin People's Republic of China"},{"name":"Key Laboratory of Sustainable Forest Ecosystem Management\u2010Ministry of Education Northeast Forestry University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Forestry Northeast Forestry University Harbin People's Republic of China"},{"name":"Key Laboratory of Sustainable Forest Ecosystem Management\u2010Ministry of Education Northeast Forestry University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"He","sequence":"additional","affiliation":[{"name":"School of Forestry Northeast Forestry University Harbin People's Republic of China"},{"name":"Key Laboratory of 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