{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:14:59Z","timestamp":1785388499796,"version":"3.55.0"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T00:00:00Z","timestamp":1107734400000},"content-version":"vor","delay-in-days":3690,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arch Insect Biochem Physiol"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently progress has been made on O<jats:sub>2<\/jats:sub> toxicity and pathology related to numerous environmental contaminants in insects. The pro\u2010oxidants studied included: dioxin, paraquat, and an assorted array of quinones, 8\u2010methoxypsorlen, arsenic, and mercury. The responses to these oxidants are diverse, but they arise from the reactive oxygen species. These pro\u2010oxidants in insects cause lipid peroxidation, protein and enzyme oxidation, and GSH depletion. Potentially, they may also cause DNA oxidation, and form DNA adducts. Oxidative challenge is alleviated by antioxidant compounds, but more importantly by the induction of antioxidant enzymes, which are crucial for the termination of O<jats:sub>2<\/jats:sub> radical cascade and lipid peroxidation chain reaction. Insects exhibit a wasting syndrome under sub\u2010acute stress. In acute toxicity vital physiological processes impaired are hemolymph melanization and diuresis. Thus, insects resemble vertebrates in both the response to oxidative stress and its pathological consequences. These results raise the prospect that insects may serve as non\u2010mammalian model species for monitoring the oxidative\u2010stress component of environmental toxicity. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/arch.940290205","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T07:52:03Z","timestamp":1109231523000},"page":"135-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Oxidative stress from environmental pollutants"],"prefix":"10.1002","volume":"29","author":[{"given":"Sami","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-1978(92)90040-K"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9689-9_7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-1790(88)90111-4"},{"key":"e_1_2_1_6_1","first-page":"109","article-title":"Corrigendum","volume":"19","author":"Ahmad S","year":"1989","journal-title":"Insect Biochem"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90107-T"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1990.tb01715.x"},{"key":"e_1_2_1_9_1","first-page":"344","article-title":"An insect model for research on detoxication of pro\u2010oxidants","volume":"33","author":"Ahmad S","year":"1991","journal-title":"Proc Amer Soc Pharmacol Exp Ther Meeting: Pharmacologist"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.940060203"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"AhmadS MacGillRS ZamanK BatcabeJP PardiniRS(1995): Dichlone\u2010induced oxidative stress in a model insect species.Arch Environ Contam Toxicol(in press).","DOI":"10.1007\/BF00208372"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(87)90119-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(78)90093-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-092545-5.50013-4"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90210-A"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(94)90216-X"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9689-9_5"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.940290204"},{"key":"e_1_2_1_19_1","first-page":"427","volume-title":"Oxy\u2010Radicals in Molecular Biology and Pathology","author":"Borg DC","year":"1988"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(87)90003-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9689-9_1"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9689-9_2"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90085-5"},{"key":"e_1_2_1_24_1","volume-title":"The Biochemical Mode of Action of Pesticides","author":"Corbett JR","year":"1974"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1016\/S0021-9258(17)35747-2","article-title":"Redox cycling of anthracyclines by cardiac mitochondria","volume":"261","author":"Doroshow JH","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_1_26_1","first-page":"77","volume-title":"Comprehensive Insect Physiology, Biochemistry, and Pharmacology","author":"Downer RGH","year":"1995"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01705426"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9689-9_10"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.940290208"},{"key":"e_1_2_1_30_1","first-page":"582","volume-title":"Casarett and Doull's Toxicology. 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