{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:11:40Z","timestamp":1697692300004},"reference-count":2,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":13413,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1970,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Es wurde der Einflu\u00df der Substituenten auf die pKa<jats:sub>base<\/jats:sub>\u2010 und pKa<jats:sub>acid<\/jats:sub>\u2010Werte f\u00fcr eine Reihe neuer morpholino\u2010alkyl\u2010substituierter Barbiturs\u00e4uren untersucht. Dabei wurde gefunden:<\/jats:p><jats:p>1. Von gr\u00f6\u00dfter Bedeutung f\u00fcr die pKa<jats:sub>base<\/jats:sub>\u2010Werte ist der Morpholinrest, welcher die M\u00f6glichkeit zur Keto\u2010Enol\u2010 und Laktam\u2010Laktim\u2010Tautomerie bietet.<\/jats:p><jats:p>2. Eine schw\u00e4chere Erh\u00f6hung des basischen Charakters ergibt die Vergr\u00f6\u00dferung des Abstandes des Morpholinrestes vom Barbiturring.<\/jats:p><jats:p>3. Sowohl pKa<jats:sub>base<\/jats:sub> als auch pKa<jats:sub>acid<\/jats:sub> werden erniedrigt, wenn der \u00c4thylrest durch einen Phenylrest am C\u20105 ersetzt wird.<\/jats:p><jats:p>4. Die pharmakologische Wirkung h\u00e4ngt vom Ionisationsgrad beim pH des Blutplasmas ab.<\/jats:p>","DOI":"10.1002\/ardp.19703031102","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T01:00:32Z","timestamp":1161046832000},"page":"868-871","source":"Crossref","is-referenced-by-count":0,"title":["Struktur und Wirkung von morpholinoalkylsubstituierten Barbiturs\u00e4uren. 2. Mitt.: Einflu\u00df der Substituenten auf die Ionisationskonstanten und die pharmakologische Wirkung"],"prefix":"10.1002","volume":"303","author":[{"given":"J.","family":"Gagausov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Michailova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Natscheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"e_1_2_1_1_2","volume":"16","author":"Gagausov J.","year":"1966","journal-title":"Pharmazie"},{"key":"e_1_2_1_2_2","unstructured":"D.Michailova R.NatschevaundJ.Gagausov im Druck."}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.19703031102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.19703031102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:54:24Z","timestamp":1697604864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.19703031102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,1]]},"references-count":2,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1970,1]]}},"alternative-id":["10.1002\/ardp.19703031102"],"URL":"https:\/\/doi.org\/10.1002\/ardp.19703031102","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,1]]}}}