{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:25:00Z","timestamp":1789525500628,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T00:00:00Z","timestamp":1158969600000},"content-version":"vor","delay-in-days":11953,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Die Anlagerung von Formaldehyd an 1\u2010Cyan\u2010homoisochroman (<jats:bold>1<\/jats:bold>) f\u00fchrt zu 1\u2010Hydroxymethyl\u20101\u2010cyan\u2010homoisochroman (<jats:bold>2<\/jats:bold>), das sich mit Benzoylchlorid oder Phenylisocyanat zum Ester <jats:bold>3<\/jats:bold> bzw. Urethan <jats:bold>4<\/jats:bold> substituieren und mit Lithiumalanat zu 1\u2010Aminomethyl\u20101\u2010hydroxymethyl\u2010homoisochroman (<jats:bold>7<\/jats:bold>) reduzieren l\u00e4\u00dft. Aus <jats:bold>7<\/jats:bold> und Aldehyden entstehen Spiro\u20101,3\u2010oxazine <jats:bold>8<\/jats:bold>. \u2013 Alkyl\u2010 oder Arylisothiocyanate \u00fcberf\u00fchren <jats:bold>1<\/jats:bold> in sek. Amide der 1\u2010Cyan\u2010homoisochroman\u20101\u2010thiocarbons\u00e4ure (<jats:bold>5<\/jats:bold>). \u2013 Die Cyan\u00e4thylierung von <jats:bold>1<\/jats:bold> mit Acrylnitril liefert 1\u2010Cyan\u20101\u2010[2\u2032\u2010cyan\u00e4thyl]\u2010homoisochroman (<jats:bold>9<\/jats:bold>), dessen Verseifung zur Dicarbons\u00e4ure <jats:bold>10a<\/jats:bold> f\u00fchrt, die sich mit Diazomethan in den Methylester <jats:bold>10b<\/jats:bold> und \u00fcber ihr Ammoniumsalz in das cyclische Imid <jats:bold>11<\/jats:bold> umwandeln l\u00e4\u00dft.<\/jats:p>","DOI":"10.1002\/ardp.19743070607","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T19:42:12Z","timestamp":1161027732000},"page":"437-442","source":"Crossref","is-referenced-by-count":4,"title":["Elektrophile Additionsreaktionen an 1\u2010Cyan\u2010homoisochroman 3. Mitt. \u00fcber Untersuchungen in der Homoisochroman\u2010Reihe"],"prefix":"10.1002","volume":"307","author":[{"given":"H.","family":"B\u00f6hme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Hitzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19733061210"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.19707340120"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19703030307"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-1973-22194"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19683010711"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.19743070607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.19743070607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T02:23:33Z","timestamp":1697595813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.19743070607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1002\/ardp.19743070607"],"URL":"https:\/\/doi.org\/10.1002\/ardp.19743070607","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}