{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T06:42:26Z","timestamp":1697697746371},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T00:00:00Z","timestamp":1158969600000},"content-version":"vor","delay-in-days":11223,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1976,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Es wurden drei Identit\u00e4tsreaktionen des Phenobarbitals in konzentrierter Schwefels\u00e4ure untersucht.<\/jats:p><jats:p>(1) Mit Natriumnitrit in konz. Schwefels\u00e4ure gibt Phenobarbital einen orangegef\u00e4rbten EDA\u2010Komplex (Ph. Eur.),<\/jats:p><jats:p>(2) Mit \u00fcbersch\u00fcssigem Formaldehyd in 83, 7proz. Schwefels\u00e4ure gibt Phenobarbital eine weinrote F\u00e4rbung (DAB 7). Sie beruht auf der Bildung von Carbeniumionen. Als Endprodukt der Reaktion wurde ein gelbliches, \u00fcber Methylen\u2010 und Polyoxymethylenbr\u00fccken stark vernetztes Produkt gefunden.<\/jats:p><jats:p>(3) Die Reaktion des Phenobarbitals mit Piperonal in 96 proz. Schwefels\u00e4ure (DAB 7\u2010DDR) ist eine Reaktion des abgespaltenen Formaldehyds. Auf 1 Mol Phenobarbital kommen dabei nur 1\/13 Mol HCHO. In der stark konzentrierten Schwefels\u00e4ure entsteht eine Chinonstruktur ohne Vernetzungen, die die Gr\u00fcnf\u00e4rbung erkl\u00e4rt \u2013 Piperonal kann in der Reaktion durch andere Formaldehyddonatoren wie z.B. Hexamethylentetramin oder Trioxan ersetzt werden.<\/jats:p>","DOI":"10.1002\/ardp.19763091208","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T20:54:43Z","timestamp":1161032083000},"page":"988-994","source":"Crossref","is-referenced-by-count":1,"title":["Zur Analytik phenylsubstituierter Barbiturate in konzentrierter Schwefels\u00e4ure"],"prefix":"10.1002","volume":"309","author":[{"given":"Harry","family":"Auterhoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Streck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"257","volume":"64","author":"Zamparo A.","year":"1925","journal-title":"Boll. Chim. Farm."},{"key":"e_1_2_1_2_2","first-page":"66","volume":"11","author":"Lobanov V. I.","year":"1962","journal-title":"Aptechn. Delo"},{"key":"e_1_2_1_3_2","first-page":"227","volume":"52","author":"Bousqet E. W.","year":"1930","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_1_4_2","first-page":"261","volume":"50","author":"Wiegrebe W.","year":"1975","journal-title":"Pharm. Acta Helv."},{"key":"e_1_2_1_5_2","first-page":"1","volume":"9","author":"Dimitrov D.","year":"1962","journal-title":"God. Khim. Tekhnol. Inst."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1135\/cccc19671449"},{"key":"e_1_2_1_7_2","first-page":"482","volume":"67","author":"Ekkert L.","year":"1926","journal-title":"Pharm. Zentralhalle Dtschl."},{"key":"e_1_2_1_8_2","volume-title":"T\u00fcpfelanalyse, Organ. Teil","author":"Feigl F.","year":"1960"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19743071208"},{"key":"e_1_2_1_10_2","first-page":"294","volume":"29","author":"B\u00fcchi J.","year":"1954","journal-title":"Pharm. Acta Helv."},{"key":"e_1_2_1_11_2","first-page":"1061","volume":"99","author":"Kala H.","year":"1959","journal-title":"Dtsch. Apoth. Ztg."}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.19763091208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.19763091208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:14:23Z","timestamp":1697663663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.19763091208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1976,1]]}},"alternative-id":["10.1002\/ardp.19763091208"],"URL":"https:\/\/doi.org\/10.1002\/ardp.19763091208","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,1]]}}}