{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:32:15Z","timestamp":1699788735183},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T00:00:00Z","timestamp":1158969600000},"content-version":"vor","delay-in-days":10857,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Die pharmakologische Pr\u00fcfung der Enantiomere einer Serie von Hexobarbital\u2010 und N\u2010Methylphenobarbital\u2010Derivaten hat ergeben, da\u00df ihre hypnotische Wirkung stereospezifisch ist. Der Barbituratrezeptor mu\u00df daher stereoselektiv sein.<\/jats:p><jats:p>Aus den stabilsten Konformationen der wirksamen Molek\u00fcle, die mit der Extended H\u00fcckel\u2010Theorie (EHT)\u2010Molekular Orbital Methode berechnet wurden, wird eine r\u00e4umliche Vorstellung der Topographie des Rezeptors abgeleitet.<\/jats:p>","DOI":"10.1002\/ardp.19773100807","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T22:18:37Z","timestamp":1161037117000},"page":"650-662","source":"Crossref","is-referenced-by-count":12,"title":["Molekular Orbital Berechnungen zur Struktur des Barbituratrezeptors"],"prefix":"10.1002","volume":"310","author":[{"given":"Hans\u2010Dieter","family":"H\u00f6ltje","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/218069a0"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00771a057"},{"key":"e_1_2_1_3_2","first-page":"709","volume":"175","author":"B\u00fcch H. P.","year":"1970","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501159"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19723050111"},{"key":"e_1_2_1_6_2","first-page":"443","volume":"27","author":"Knabe J.","year":"1972","journal-title":"Pharmazie"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.19707390104"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1734456"},{"key":"e_1_2_1_9_2","unstructured":"Indiana University Quantum Chemistry Program Exchange No. 64."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00254a007"},{"key":"e_1_2_1_11_2","first-page":"360","volume":"10","author":"Pullman B.","year":"1974","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(72)90045-8"},{"key":"e_1_2_1_13_2","first-page":"470","volume":"11","author":"Daves G. D.","year":"1975","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1727227"},{"key":"e_1_2_1_15_2","unstructured":"Indiana University Quantum Chemistry Program Exchange No. 141."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19773100613"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19743071214"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19763090106"},{"key":"e_1_2_1_19_2","unstructured":"J. P.Bideau Th\u00e8se L'Universit\u00e9 de Bordeaux I1971."},{"key":"e_1_2_1_20_2","volume-title":"Tables of Interatomic Distances and Configuration in Molecules and Ions","year":"1965"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.19773100807","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.19773100807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T19:32:39Z","timestamp":1697657559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.19773100807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1002\/ardp.19773100807"],"URL":"https:\/\/doi.org\/10.1002\/ardp.19773100807","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}