{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T03:19:51Z","timestamp":1699240791077},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T00:00:00Z","timestamp":1158969600000},"content-version":"vor","delay-in-days":9031,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Die Synthese von Chinolon\u2010 und Barbiturs\u00e4urederivaten mit Strukturanalogien zu den oralen Antikoagulantien Phenprocoumon, Warfarin und Diphenadion wird beschrieben. Das Chinolon <jats:bold>3<\/jats:bold> und die 5\u2010Acylbarbiturs\u00e4uren <jats:bold>8<\/jats:bold> liegen in enolisierter Form vor. Die warfarinanalogen 5\u2010Alkylbarbiturs\u00e4uren <jats:bold>5<\/jats:bold> sind enolisierbar. Alle Substanzen wurden einmalig oral an Ratten verabreicht (330mg\/kg) und zeigten keine antikoagulante Wirkung. In \u00dcbereinstimmung mit der <jats:italic>Silverman<\/jats:italic>\u2010Hypothese f\u00fcr die Vit.\u2010K\u2010Epoxidase\u2010Hemmung wird die Ursache f\u00fcr die Wirkungslosigkeit in der geringen Reaktionsbereitschaft der Titelverbindungen gegen\u00fcber Nucleophilen gesehen.<\/jats:p>","DOI":"10.1002\/ardp.19823150605","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T22:15:56Z","timestamp":1161123356000},"page":"502-509","source":"Crossref","is-referenced-by-count":5,"title":["Zur Strukturabh\u00e4ngigkeit antikoagulanter Wirkungen: Barbiturs\u00e4uren und Chinolone"],"prefix":"10.1002","volume":"315","author":[{"given":"Klaus","family":"Rehse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf\u2010Dieter","family":"Kapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"541","volume":"201","author":"Ren P.","year":"1977","journal-title":"J. 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