{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:20:21Z","timestamp":1758478821592},"reference-count":2,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T00:00:00Z","timestamp":1158969600000},"content-version":"vor","delay-in-days":6474,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Die Bindung von 13 nichtsteroidalen Antirheumatika an Humanserumalbumin (HSA) wurde gemessen. Durch Diflunisal wurde die freie Konzentration von Phenprocoumon dosisabh\u00e4ngig um bis zu 35% gesteigert. Piroxicam und Ibuprofen zeigten nahezu keine Wechselwirkung mit Phenprocoumon. Aus den Ergebnissen wird gefolgert, da\u00df Ibuprofen nicht und Diflunisal nur in geringem Ausma\u00df an die Phenprocoumonbindungsstelle des HSA angelagert wird.<\/jats:p>","DOI":"10.1002\/ardp.19893220410","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T17:06:47Z","timestamp":1161018407000},"page":"241-243","source":"Crossref","is-referenced-by-count":10,"title":["Untersuchungen zur Eiwei\u00dfbindung von Arzneistoffen durch kontinuierliche Ultrafiltration, 9. Mitt. Vergleichende Untersuchungen zur Bindung nichtsteroidaler Antirheumatika an Humanserumalbumin und deren Interaktion mit Phenprocoumon"],"prefix":"10.1002","volume":"322","author":[{"given":"Klaus","family":"Rehse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19873200309"},{"key":"e_1_2_1_3_2","first-page":"1052","volume":"12","author":"Sudlow G.","year":"1976","journal-title":"Mol. Pharmacol."}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.19893220410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.19893220410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T14:36:56Z","timestamp":1697639816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.19893220410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":2,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1002\/ardp.19893220410"],"URL":"https:\/\/doi.org\/10.1002\/ardp.19893220410","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}