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Die in Ethanol rechtsdrehenden Enantiomere von <jats:bold>2a\u20102d<\/jats:bold> besitzen S\u2010Konfiguration. \u2010 Die Pr\u00fcfung von Ratten ergab. da\u00df alle synthetisierten zyklischen Harnstoffe sedativ\u2010hypnotische Wirksamkeit besitzen. Die Enantiomere wiesen zum Teil beachtliche enantioselektive Wirkungsunterschiede auf.<\/jats:p>","DOI":"10.1002\/ardp.19933260205","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T11:21:53Z","timestamp":1161084113000},"page":"79-84","source":"Crossref","is-referenced-by-count":8,"title":["Zyklische Harnstoffe, 1. Mitt.: Racemate und Enantiomere von Hexahydropyrimidin\u20102\u2010onen: Synthese, Konfiguration und sedativ\u2010hypnotische Wirkung"],"prefix":"10.1002","volume":"326","author":[{"given":"Joachim","family":"Knabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst P.","family":"B\u00fcch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Biwersi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"211","volume":"54","author":"de Beer E. J.","year":"1934","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_2_3","first-page":"474","volume":"10","author":"Mrongovius R. I.","year":"1975","journal-title":"Eur. J. Med. Chim. 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