{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:58:06Z","timestamp":1774648686099,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":5012,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of 19 <jats:italic>N<\/jats:italic>\u2010alkyl\u2010diarylpyrrolyl\u2010acetic and \u2010propionic acid derivatives was synthesized and tested. Using bovine blood as enzyme source the inhibition of cyclooxygenase and 5\u2010lipoxygenase, respectively, was applied to determine the antiinflammatory activity. In general all compounds tested inhibit 5\u2010lipoxygenase more effectively than cyclooxygenase. A structure\u2010activity relationship is discussed.<\/jats:p>","DOI":"10.1002\/ardp.19933260308","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T11:24:11Z","timestamp":1161084251000},"page":"157-162","source":"Crossref","is-referenced-by-count":17,"title":["Nonsteriodal Antiinflammatory Agents, XVII: Inhibition of Bovine Cyclooxygenase and 5\u2010Lipoxygenase by <i>N<\/i>\u2010Alkyldiphenyl\u2010pyrrolyl Acetic and Propionic Acid Derivatives"],"prefix":"10.1002","volume":"326","author":[{"given":"G.","family":"Dannhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"244","volume":"114","author":"Dannhardt G.","year":"1990","journal-title":"Chemiker\u2010Ztg."},{"key":"e_1_2_1_3_2","first-page":"1","volume":"2","author":"Shen T. Y.","year":"1977","journal-title":"Drugs Exptl. Clin. Res."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19883210911"},{"key":"e_1_2_1_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19883210310"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1139\/v77-583"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1071\/CH9661871"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1992.tb03636.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)88835-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)80714-8"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.19933260308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.19933260308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:06:47Z","timestamp":1697602007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.19933260308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/ardp.19933260308"],"URL":"https:\/\/doi.org\/10.1002\/ardp.19933260308","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}