{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T06:42:41Z","timestamp":1697697761625},"reference-count":7,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T00:00:00Z","timestamp":1158969600000},"content-version":"vor","delay-in-days":5013,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies are described on the metabolism of the enantiomers of <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold>, and <jats:bold>3<\/jats:bold> in rats. The metabolites were identified in urine after cleavage of conjugates and extraction using gas chromatography\u2010mass spectrometry. Qualitative enantioselective differences of the metabolism of <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold>, and <jats:bold>3<\/jats:bold> could not be detected. Because oxidation of <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> to the corresponding barbiturates could not be found and <jats:bold>3<\/jats:bold> was oxidized to mephenytoin only in minor amounts, this pathway is not a prerequisite for the sedative\u2010hypnotic effects of <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold>, and <jats:bold>3<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/ardp.19933260908","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T11:53:41Z","timestamp":1161086021000},"page":"535-538","source":"Crossref","is-referenced-by-count":0,"title":["Cyclic Ureas, III: On the Metabolism of the Enantiomers of Cyclic Ureas in Rats"],"prefix":"10.1002","volume":"326","author":[{"given":"Hans H.","family":"Maurer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Biwersi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Knabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19933260605"},{"key":"e_1_2_1_3_2","unstructured":"J.Biwersi Dissertation Univ. des Saarlandes Saarbr\u00fccken 1990."},{"key":"e_1_2_1_4_2","first-page":"787","volume":"323","author":"Maurer H. H.","year":"1990","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"e_1_2_1_5_2","first-page":"1048","volume":"28","author":"Knabe J.","year":"1978","journal-title":"Arzneim. Forsch."},{"key":"e_1_2_1_6_2","first-page":"474","volume":"10","author":"Mrongovius R. I.","year":"1975","journal-title":"Eur. J. Med. Chim. Ther."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19933260205"},{"key":"e_1_2_1_8_2","volume-title":"Mass Spectral and GC Data of Drugs, Pesticides, Poisons and Their Metabolites","author":"Maurer H. H.","year":"1992"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.19933260908","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.19933260908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:21:08Z","timestamp":1697610068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.19933260908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":7,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/ardp.19933260908"],"URL":"https:\/\/doi.org\/10.1002\/ardp.19933260908","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}