{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T23:12:11Z","timestamp":1762125131987},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T00:00:00Z","timestamp":1158969600000},"content-version":"vor","delay-in-days":5013,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifteen 3\u2010alkyl\u2010, four 3\u2010cycloalkyl\u2010<jats:italic>N<\/jats:italic>\u2010nitroso\u20105\u2010sydnone imines and five 3\u2010alkyl\u2010<jats:italic>N<\/jats:italic>\u2010nitro\u20105\u2010sydnone imines were synthesized and their ability to inhibit platelet aggregation induced by collagen (<jats:italic>Born<\/jats:italic>\u2010test) was studied <jats:italic>in vitro<\/jats:italic>. Dependent on the chemical structure, the IC<jats:sub>50<\/jats:sub>\u2010values for the inhibition of platelet aggregation were in the range of 0.2\u2010140 \u03bcmol\/L. It is suggested that this scale reflects different binding properties of the nitrosimines with respect to the platelet membrane. Highest activities were observed for the 3\u2010hexyl (<jats:bold>2f<\/jats:bold>) and the 3\u2010cyclohexyl (<jats:bold>2p<\/jats:bold>) derivative. Three nitrimines (<jats:bold>3e, 3f, 3i<\/jats:bold>) also showed IC<jats:sub>50<\/jats:sub> values below 10 \u03bcmol\/L. For the nitrosimines <jats:bold>2a, 2f<\/jats:bold>, and <jats:bold>2m<\/jats:bold> antithrombotic activity was demonstrated <jats:italic>in vivo<\/jats:italic>. They inhibited laser induced arterial thrombosis in anesthetized rats up to 70% two h after oral administration. In conscious renal\u2010hypertensive dogs, the decrease in systolic blood pressure and left ventricular enddiastolic pressure suggests an antianginal activity of the compound <jats:bold>2a<\/jats:bold> similar to that of molsidomine (M). The smoother onset and the longer duration of action of the new compound as compared to M could be a significant advantage of <jats:bold>2a<\/jats:bold> in the therapy of angina pectoris.<\/jats:p>","DOI":"10.1002\/ardp.19933261005","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T10:43:11Z","timestamp":1161081791000},"page":"791-797","source":"Crossref","is-referenced-by-count":14,"title":["New NO\u2010Donors with Antithrombotic and Vasodilating Activities, II: 3\u2010Alkyl\u2010<i>N<\/i>\u2010nitroso\u20105\u2010sydnone Imines"],"prefix":"10.1002","volume":"326","author":[{"given":"Klaus","family":"Rehse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2010J\u00fcrgen","family":"Schleifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ciborski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Bohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19933260811"},{"key":"e_1_2_1_3_2","first-page":"941","volume":"13","author":"Rehse K.","year":"1988","journal-title":"Drugs of the Future"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19913240509"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-05748-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/12.suppl_E.33"},{"key":"e_1_2_1_7_2","first-page":"708","volume":"232","author":"Martin W.","year":"1985","journal-title":"J. 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