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Der Verlust des basischen Seitenketten\u2010Stickstoffs f\u00fchrt am H<jats:sub>1<\/jats:sub>\u2010Rezeptor des Meerschweinchenileums zu einem Abfall der Aktivit\u00e4t im Vergleich zu den betreffenden Referenzsubstanzen mit gleicher H<jats:sub>1<\/jats:sub>\u2010Partialstruktur. Am Meerschweinchenatrium (H<jats:sub>2<\/jats:sub>\u2010Rezeptormodell) erwiesen sich Verbindungen mit Mepyramin\u2010 und Cyclizinstrukturelement im Vergleich zu den Referenz\u2010H<jats:sub>2<\/jats:sub>\u2010Antagonisten (Tiotidin, Ranitidin, Lamtidin) ebenfalls als schw\u00e4cher wirksam. Dagegen f\u00fchrt die Verkn\u00fcpfung mit einem Pheniraminbaustein zu stark wirksamen H<jats:sub>2<\/jats:sub>\u2010Antagonisten, die bis zu 27fache Cimetidinaktivit\u00e4t erreichen.<\/jats:p>","DOI":"10.1002\/ardp.19943270708","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T01:40:40Z","timestamp":1161049240000},"page":"455-462","source":"Crossref","is-referenced-by-count":7,"title":["Synthese und kombinierte H<sub>1<\/sub>\u2010\/H<sub>2<\/sub>\u2010antagonistische Aktivit\u00e4t von Mepyramin\u2010, Pheniramin\u2010 und Cyclizin\u2010Derivaten mit Cyanoguanidin\u2010, Harnstoff\u2010 und Nitroethendiamin\u2010Partialstrukturen"],"prefix":"10.1002","volume":"327","author":[{"given":"Frank R.","family":"Schulze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudi A.","family":"Alisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Buschauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Schunack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854185779048997"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700170143"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.1.1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01745343"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80241-6"},{"key":"e_1_2_1_7_2","first-page":"751ff.","volume-title":"Anaesthesie","author":"Larsen R.","year":"1987"},{"key":"e_1_2_1_8_2","first-page":"437p","volume":"80","author":"Blakemore R. 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