{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T06:10:29Z","timestamp":1696831829076},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T00:00:00Z","timestamp":1158969600000},"content-version":"vor","delay-in-days":4283,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The combined effects of the oligoamine RE 1492 with the NO\u2010donor RE 2047 or ASA, ticlopidine, pentoxifylline and BM 14515 were determined <jats:italic>in vitro (Born\u2010test<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> (rat thrombosis model). The effects <jats:italic>in vitro<\/jats:italic> were supra additive but over independent. <jats:italic>In vivo<\/jats:italic> all combinations showed over additive and over independent inhibition of thrombus formation. The best results were obtained with a combination of 10 mg\/kg RE 1492C and 10 mg\/kg RE 2047. It inhibited thrombus formation in arterioles (A) by 79 % and 36 % in venoles (V). The combined effect of RE 1492C and pentoxifylline 10 mg\/kg each was 62% (A) or 32% (V), respectively.<\/jats:p>","DOI":"10.1002\/ardp.19953280408","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T21:43:39Z","timestamp":1161121419000},"page":"333-337","source":"Crossref","is-referenced-by-count":1,"title":["Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXVI: Antiplatelet and Antithrombotic Effects of the Oligoamine RE 1492 in Combination with Standard and Future Antithrombotic Drugs"],"prefix":"10.1002","volume":"328","author":[{"given":"Klaus","family":"Rehse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ciborski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002698"},{"key":"e_1_2_1_3_2","first-page":"277","volume":"11","author":"Giedrojc I.","year":"1992","journal-title":"Int. J. Microcirc. Clin. Exp."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(91)90533-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(93)90082-Y"},{"key":"e_1_2_1_6_2","first-page":"7","volume":"105","author":"Bieron K.","year":"1993","journal-title":"Wien. Klin. Wochenschr."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-3484-2_1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(92)90005-U"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.198700039"},{"key":"e_1_2_1_10_2","first-page":"941","volume":"13","author":"Rehse K.","year":"1988","journal-title":"Drugs Future"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19913240509"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.2503241005"},{"key":"e_1_2_1_13_2","first-page":"451","volume":"3","author":"Gent M.","year":"1989","journal-title":"Lancet"},{"key":"e_1_2_1_14_2","first-page":"737","volume":"6","author":"Ariens E. J.","year":"1956","journal-title":"Arzneim. Forsch."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(80)90036-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19883211110"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19813140710"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-05748-3"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.19953280408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.19953280408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T07:34:35Z","timestamp":1696750475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.19953280408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/ardp.19953280408"],"URL":"https:\/\/doi.org\/10.1002\/ardp.19953280408","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}