{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T19:02:14Z","timestamp":1698433334692},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":3917,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nineteen 4\u2010substituted 1,2,4\u2010oxadiazol\u20105\u2010ones (<jats:bold>6a\u2010s<\/jats:bold>) were prepared as prodrugs for lipophilic hydroxyguanidines which should be metabolized <jats:italic>in vivo<\/jats:italic> to nitric oxide. This hypothesis was tested indirectly by measuring the antithrombotic properties of these compounds 2 h after oral administration to rats (60 mg\/kg). In mesenteric arterioles seven compounds moderately (\u2265 10%) inhibited the formation of thrombi by a laser beam. Maximum effects were observed in <jats:bold>6c<\/jats:bold> (4\u2010pentyl) and <jats:bold>6f<\/jats:bold> (4\u2010benzyl). The lack of activity in the corresponding 2\u2010pentyloxadiazolone <jats:bold>10c<\/jats:bold>, where no formation of nitric oxide seems possible, indirectly suggests that the antithrombotic properties of the title compounds could be mediated by the <jats:italic>in vivo<\/jats:italic> formation of nitric oxide.<\/jats:p>","DOI":"10.1002\/ardp.19963291205","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T16:48:30Z","timestamp":1161017310000},"page":"535-540","source":"Crossref","is-referenced-by-count":5,"title":["New NO\u2010Donors with Antithrombotic and Vasodilating Activities, Part 16 3\u2010Amino\u20101,2,4\u2010oxadiazol\u20105\u2010ones as Prodrugs for Hydroxyguanidines"],"prefix":"10.1002","volume":"329","author":[{"given":"Klaus","family":"Rehse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Bade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1016\/S0021-9258(18)38112-2","volume":"226","author":"Stuehr D. 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