{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:29:21Z","timestamp":1762673361629},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,1,28]],"date-time":"2004-01-28T00:00:00Z","timestamp":1075248000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, amide derivatives of [6\u2010(5\u2010methyl\u20103\u2010phenyl\u2010pyrazole\u20101\u2010yl)\u20103(2H)\u2010pyridazinone\u20102\u2010yl]acetic acid were synthesized and tested for their <jats:italic>in vivo<\/jats:italic> analgesic and anti\u2010inflammatory activity by using the <jats:italic>p<\/jats:italic>\u2010benzoquinone\u2010induced writhing test and carrageenan\u2010induced hind paw edema model, respectively. The analgesic and anti\u2010inflammatory activity of the compounds <jats:bold>6a<\/jats:bold>, <jats:bold>6d<\/jats:bold>, <jats:bold>6e<\/jats:bold>, <jats:bold>6g<\/jats:bold>, <jats:bold>6h<\/jats:bold> and <jats:bold>6m<\/jats:bold> were more potent than that of aspirin as an analgesic and indomethacin as an anti\u2010inflammatory drug, respectively. The other derivatives generally resulted in comparable activity to reference compounds. Inhibitor activity of the active compounds on cyclooxygenase isoforms was also investigated by using <jats:italic>in vitro<\/jats:italic> human whole blood assay and found that these derivatives did not exert their analgesic and anti\u2010inflammatory activities through COX inhibition and other mechanisms might be involved.<\/jats:p>","DOI":"10.1002\/ardp.200200738","type":"journal-article","created":{"date-parts":[[2004,1,30]],"date-time":"2004-01-30T10:00:41Z","timestamp":1075456841000},"page":"7-14","source":"Crossref","is-referenced-by-count":36,"title":["Amide Derivatives of [6\u2010(5\u2010Methyl\u20103\u2010phenylpyrazole\u20101\u2010yl)\u20103(2H)\u2010pyridazinone\u20102\u2010yl]acetic Acids as Potential Analgesic and Anti\u2010Inflammatory Compounds"],"prefix":"10.1002","volume":"337","author":[{"given":"Erden","family":"Banoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fla","family":"Ako\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"\u00dcnl\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"K\u00fcpeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdem","family":"Ye\u015filada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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