{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:51:41Z","timestamp":1775127101455,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a search for promising antibacterial and antifungal compounds, two new series of 2, 3\u2010<jats:italic>bis<\/jats:italic>(5\u2010alkyl\u20102\u2010thiono\u20101, 3, 5\u2010thiadiazin\u20103\u2010yl)propionic acid <jats:bold>1<\/jats:bold> and their corresponding <jats:italic>N, N<\/jats:italic>\u2010dimethylpropionamide <jats:bold>6<\/jats:bold> have been synthesized. The reaction of 2, 3\u2010diaminopropionate <jats:bold>3<\/jats:bold>, carbon disulfide, formaldehyde, and the appropriate alkyl amines furnished the title compound <jats:bold>1<\/jats:bold>. <jats:italic>N, N<\/jats:italic>\u2010dimethylpropionamides <jats:bold>6<\/jats:bold> were obtained by the reaction of <jats:bold>1<\/jats:bold> with dimethyl amine in the presence of POCl<jats:sub>3<\/jats:sub>. The newly prepared compounds were screened <jats:italic>in vitro<\/jats:italic> against certain strains of Gram\u2010positive and Gram\u2010negative bacteria and compared with nalidixic acid and ciprofloxacin. Moreover, the title compounds were tested for their antifungal activity <jats:italic>in vitro<\/jats:italic> against <jats:italic>Candida albicans<\/jats:italic>, phytopathogenic, <jats:italic>Penicillum expansum<\/jats:italic> and <jats:italic>Trichoderma hazianum<\/jats:italic>, and aflatoxin\u2010producing <jats:italic>Aspergillus flavus<\/jats:italic>. These compounds exhibit varied activity against the tested pathogenic bacteria and remarkable inhibitory effects on growth or sporulation of some of the tested fungal species.<\/jats:p>","DOI":"10.1002\/ardp.200400906","type":"journal-article","created":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T12:19:43Z","timestamp":1106828383000},"page":"38-43","source":"Crossref","is-referenced-by-count":25,"title":["2, 3\u2010Bis(5\u2010alkyl\u20102\u2010thiono\u20101, 3, 5\u2010thiadiazin\u20103\u2010yl) Propionic Acid: One\u2010Pot <i>Domino<\/i> Synthesis and Antimicrobial Activity"],"prefix":"10.1002","volume":"338","author":[{"given":"Serry A. 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