{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:13:37Z","timestamp":1768011217706,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,5,2]],"date-time":"2005-05-02T00:00:00Z","timestamp":1114992000000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three simple, sensitive and accurate spectrophotometric methods have been developed for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations. These methods are based on the formation of yellow ion\u2010pair complexes between the examined drug and bromocresol green (BCG), bromocresol purple (BCP), and bromophenol blue (BPB) as sulphophthalein dyes in acetate\u2010HCl buffer of pH 3.6, 3.4, and 4.0, respectively. The formed complexes were extracted with dichloromethane and measured at 405 nm for all three systems. The best conditions of the reactions were studied and optimized. Beer's law was obeyed in the concentration ranges 2.0\u201312, 2.0\u201313, and 2.0\u201314 \u03bcg mL<jats:sup>\u22121<\/jats:sup> with molar absorptivities of 3.2 \u00d7 10<jats:sup>4<\/jats:sup>, 3.7 \u00d7 10<jats:sup>4<\/jats:sup>, and 3.1 \u00d7 10<jats:sup>4<\/jats:sup> L mol<jats:sup>\u22121<\/jats:sup> cm<jats:sup>\u22121<\/jats:sup> for the BCG, BCP, and BPB methods, respectively. Sandell's sensitivity, correlation coefficient, detection and quantification limits are also calculated. The proposed methods have been applied successfully for the analysis of the drug in pure form and in its dosage forms. No interference was observed from common pharmaceutical excipients. Statistical comparison of the results with those obtained by HPLC method shows excellent agreement and indicates no significant difference in accuracy and precision.<\/jats:p>","DOI":"10.1002\/ardp.200400947","type":"journal-article","created":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T13:40:28Z","timestamp":1115127628000},"page":"190-197","source":"Crossref","is-referenced-by-count":17,"title":["Extractive Spectrophotometric Methods for the Determination of Oxomemazine Hydrochloride in Bulk and Pharmaceutical Formulations Using Bromocresol Green, Bromocresol Purple and Bromophenol Blue"],"prefix":"10.1002","volume":"338","author":[{"given":"Akram M.","family":"El\u2010Didamony","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,2]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"R. M.Jacob J. 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