{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T06:20:05Z","timestamp":1775370005607,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T00:00:00Z","timestamp":1173657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In search of novel purine antimetabolites, a series of 8\u2010substituted methylxanthine derivatives was prepared in order to explore their<jats:italic> in vitro <\/jats:italic>anticancer, anti\u2010HIV\u20101 and antimicrobial activities. The target compounds include: 8\u2010[(3\u2010substituted\u20104\u2010oxo\u2010thiazolidin\u20102\u2010ylidene)hydrazino]\u20101,3\u2010dimethyl (or 1,3,7\u2010trimethyl)\u20103,7\u2010dihydropurine\u20102,6\u2010diones <jats:bold>5a\u2013e<\/jats:bold>, 8\u2010[(3,4\u2010disubstituted 2,3\u2010dihydrothiazol\u20102\u2010ylidene)hydrazino]\u20101,3,7\u2010trimethyl\u20103,7\u2010dihydropurine\u20102,6\u2010diones<jats:bold> 6a\u2013d<\/jats:bold> and 8\u2010(5\u2010amino\u20103\u2010arylpyrazol\u20101\u2010yl)\u20101,3\u2010dimethyl\u2010 (or 1,3,7\u2010trimethyl)\u20103,7\u2010dihydropurine\u20102,6\u2010diones<jats:bold> 7a\u2013g<\/jats:bold>. The<jats:italic> in vitro<\/jats:italic> anticancer results revealed that compound <jats:bold>5d <\/jats:bold>exhibited a super sensitivity profile towards leukemia K\u2010562 with a GI<jats:sub>50<\/jats:sub> value of &lt;0.01 \u03bcM. Compound <jats:bold>7c <\/jats:bold>showed significant activity against colon cancer HCT\u201015 and renal cancer CAKI\u20101 (GI<jats:sub>50<\/jats:sub> values of 0.47 and 0.78 \u03bcM, respectively). Compound<jats:bold> 7a<\/jats:bold> displayed high activity against colon cancer HCT\u201015 (GI<jats:sub>50 <\/jats:sub>= 0.8 \u03bcM). The anti\u2010HIV\u20101 results indicated that compound <jats:bold>6b <\/jats:bold>displayed a good reduction of viral cytopathic effect (56.69%). The antimicrobial results showed that compound<jats:bold> 5a <\/jats:bold>was four times more active than ampicillin against<jats:italic> P. aerugenosa<\/jats:italic> (MIC = &lt;\u00a025 \u03bcg\/mL), compound<jats:bold> 5b<\/jats:bold> had twice the activity of ampicillin, while compounds<jats:bold> 5d<\/jats:bold>,<jats:bold> 7c<\/jats:bold> and<jats:bold> 7f <\/jats:bold>were equipotent to ampicillin. On the other hand, compound<jats:bold> 7a<\/jats:bold> was equipotent to ampicillin against <jats:italic>P. vulgaris<\/jats:italic> (MIC = 50 \u03bcg\/mL).<\/jats:p>","DOI":"10.1002\/ardp.200600118","type":"journal-article","created":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T09:06:45Z","timestamp":1173690405000},"page":"185-194","source":"Crossref","is-referenced-by-count":31,"title":["Synthesis of Some Novel Substituted Purine Derivatives As Potential Anticancer, Anti\u2010HIV\u20101 and Antimicrobial Agents"],"prefix":"10.1002","volume":"340","author":[{"given":"Samia M.","family":"Rida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawzia A.","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soad A.M.","family":"El\u2010Hawash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona M.","family":"El\u2010Semary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona H.","family":"Badr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.175"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb03804.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm970271t"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/138955706776876212"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00163a020"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00166a021"},{"key":"e_1_2_1_8_2","first-page":"2625","volume":"50","author":"Avery T. 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