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Some anti\u2010tumor effects are thought to be related to their cyclooxygenase\u20102\u2010inhibitory activity, but recent studies have shown that non\u2010steroidal anti\u2010inflammatory drugs exert their anti\u2010tumor effect via cyclooxygenase\u20102\u2010independent mechanism. SDX\u2010308 (CEP\u201018082) is a non\u2010cyclooxygenase\u20102\u2010inhibiting indole\u2010pyran analog and is structurally related to SDX\u2010101, an <jats:italic>R<\/jats:italic>\u2010enantiomer of etodolac. SDX\u2010308 has a potent anti\u2010myeloma effect and shows synergism in combination with other drugs for the treatment of chronic lymphocytic leukemia. In addition SDX\u2010308 inhibits osteoclast formation and activity and thereby might be an attractive drug for the treatment of diseases with increased osteoclast activity such as osteolytic lesions in multiple myeloma and metastatic carcinomas, as well as osteoporosis. This review covers future application of SDX\u2010308 as an anti\u2010myeloma drug regulating increased osteoclast activity.<\/jats:p>","DOI":"10.1002\/ardp.200700081","type":"journal-article","created":{"date-parts":[[2007,9,11]],"date-time":"2007-09-11T16:47:46Z","timestamp":1189529266000},"page":"511-516","source":"Crossref","is-referenced-by-count":9,"title":["SDX\u2010308 and SDX\u2010101, Non\u2010Steroidal Anti\u2010Inflammatory Drugs, as Therapeutic Candidates for Treating Hematologic Malignancies Including Myeloma"],"prefix":"10.1002","volume":"340","author":[{"given":"Suzanne","family":"Lentzsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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