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The novel compounds were found to be strong inhibitors of a wide variety of pathogenic microorganisms (incl. <jats:italic>Mycobacterium tuberculosis<\/jats:italic>) as well as cancer cell lines. The biological activities were generally in the same range as those previously found for the structurally more complex agelasines and agelasimines isolated in small amounts from natural sources. We also report for the first time that agelasine and agelasimine analogs inhibit growth of protozoa (<jats:italic>Acanthamoeba castellanii<\/jats:italic> and <jats:italic>Acanthamoeba polyphaga<\/jats:italic>).<jats:italic> Acanthamoeba <\/jats:italic>keratitis is an increasingly common and severe corneal infection, closely associated with contact lens wear.<\/jats:p>","DOI":"10.1002\/ardp.200700137","type":"journal-article","created":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T11:17:03Z","timestamp":1194866223000},"page":"625-634","source":"Crossref","is-referenced-by-count":36,"title":["Synthesis, Antimicrobial and Antineoplastic Activities for Agelasine and Agelasimine Analogs with a \u03b2\u2010Cyclocitral Derived Substituent"],"prefix":"10.1002","volume":"340","author":[{"given":"\u00c1gnes","family":"Proszeny\u00e1k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Charnock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Hedner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bohlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise\u2010Lotte","family":"Gundersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)81345-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(84)80114-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00318a045"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.59.2495"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/np960745b"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/np970454i"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/np980173q"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1139\/v88-006"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1139\/y89-045"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/b417471b"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2004.04.030"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/np050424c"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/b005617k"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.03.055"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(02)01455-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1975.479"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00869a029"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20017"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68384-0"},{"key":"e_1_2_1_21_2","unstructured":"F. 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