{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:05:58Z","timestamp":1788833158856,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T00:00:00Z","timestamp":1191283200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chromene derivative <jats:bold>4 <\/jats:bold>reacts with acetic anhydride, phenylisothiocyanate and ethyl orthoformate to afford the <jats:italic>N<\/jats:italic>\u2010acetyl derivative <jats:bold>6<\/jats:bold>, the chromenopyrimidine<jats:bold> 8<\/jats:bold> and the formimidate <jats:bold>9<\/jats:bold>, respectively. 2\u2010(1<jats:italic>H<\/jats:italic>\u2010Indol\u20103\u2010ylmethylene)\u2010malononitrile <jats:bold>10b<\/jats:bold> reacts with 1,3\u2010cyclohexanedione and dimedone<jats:bold> 11a<\/jats:bold>, <jats:bold>b<\/jats:bold> to afford the 4(3\u2010indolyl)\u2010chromene derivatives <jats:bold>12a<\/jats:bold>,<jats:bold> b<\/jats:bold> respectively, and with the pyrazolone derivatives<jats:bold> 13a\u2013d <\/jats:bold>to afford the arylidene exchange derivatives<jats:bold> 14a\u2013c <\/jats:bold>and the pyranopyrazole derivative <jats:bold>15<\/jats:bold>, respectively. The arylidene derivatives<jats:bold> 10a<\/jats:bold>,<jats:bold> b<\/jats:bold> react also with indane\u20101,3\u2010dione<jats:bold> 16 <\/jats:bold>to afford the arylidene exchange derivatives<jats:bold> 18a<\/jats:bold>,<jats:bold> b<\/jats:bold>. The molluscicidal activity of the synthesized compounds towards <jats:italic>Biomphalaria alexandrina<\/jats:italic> snails, the intermediate host of <jats:italic>Schistosoma mansoni<\/jats:italic>, was investigated and most of them showed weak to moderate activity.<\/jats:p>","DOI":"10.1002\/ardp.200700157","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T12:46:32Z","timestamp":1191329192000},"page":"543-548","source":"Crossref","is-referenced-by-count":227,"title":["Synthesis and Molluscicidal Activity of New Chromene and Pyrano[2,3\u2010<i>c<\/i>]pyrazole Derivatives"],"prefix":"10.1002","volume":"340","author":[{"given":"Fathy M.","family":"Abdelrazek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kataeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif F.","family":"El\u2010Mahrouky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01652a112"},{"key":"e_1_2_1_3_2","first-page":"45","volume":"11","author":"Nour El\u2010Din M.","year":"1970","journal-title":"Egypt. 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