{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T12:31:55Z","timestamp":1699360315144},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T00:00:00Z","timestamp":1200009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of 2\u2010substituted imidazo[1,2\u2010<jats:italic>a<\/jats:italic>]\u20101,3,5\u2010triazines with various aliphatic and aromatic amines has been prepared and characterized by IR,<jats:sup> 1<\/jats:sup>H\u2010NMR, and elemental analysis. The initial <jats:italic>in\u2010vitro <\/jats:italic>cytotoxicity studies with five human cancer cell lines showed that all but one of the compounds are without cytotoxic activity. The one active compound, 2\u2010(indolin\u20101\u2010yl)\u20107,8\u2010dihydroimidazo[1,2\u2010<jats:italic>a<\/jats:italic>]\u20101,3,5\u2010triazine\u20104(6<jats:italic>H<\/jats:italic>)\u2010thione<jats:bold> 12, <\/jats:bold>was tested on 12 human cancer cell lines. Of these, two lines, RT\u20104 and MCF\u20107, were the most sensitive to the compound, with IC<jats:sub>50 <\/jats:sub>values of 6.98 \u03bcM and 8.43 \u03bcM, respectively. When compared with the reference anticancer drug 6\u2010mercaptopurine, only the RT\u20104 urinary bladder and KYSE\u201070 oesophagus cancer cell lines were more sensitive to the new compound. The antimetabolite thioguanine was more cytotoxic than <jats:bold>12<\/jats:bold> for all common cell lines tested.<\/jats:p>","DOI":"10.1002\/ardp.200700176","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T11:16:44Z","timestamp":1200050204000},"page":"121-125","source":"Crossref","is-referenced-by-count":11,"title":["Synthesis and Cytotoxic Activity of Imidazo[1,2\u2010<i>a<\/i>]\u20101,3,5\u2010triazine Analogues of 6\u2010Mercaptopurine"],"prefix":"10.1002","volume":"341","author":[{"given":"Franciszek","family":"Saczewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Maruszak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Bednarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,31]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"H.Staehle H.Hoeppe W.Kummer W.Hoefke Ger. 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