{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:55:49Z","timestamp":1762541749116},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:00:00Z","timestamp":1215648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Starting point of the present paper was the result of a virtual screening using the open conformation of the large extracellular loop (LEL) of the CD81\u2010receptor (crystal structure: PDB\u2010ID: 1G8Q). After benzyl salicylate had been experimentally validated to be a moderate inhibitor of the CD81\u2010LEL\u2013HCV\u2010E2 interaction, further optimization was performed and heterocyclic\u2010substituted benzyl salicylate derivatives were synthesized. The compounds were tested for their ability to inhibit the interaction of a fluorescence\u2010labeled antibody to CD81\u2010LEL using HUH7.5 cells. No compound showed an increase concerning the inhibition of the protein\u2010protein interaction compared to benzyl salicylate.<\/jats:p>","DOI":"10.1002\/ardp.200700261","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T14:34:20Z","timestamp":1215700460000},"page":"478-484","source":"Crossref","is-referenced-by-count":11,"title":["Structural Modifications of Salicylates: Inhibitors of Human CD81\u2010Receptor HCV\u2010E2 Interaction"],"prefix":"10.1002","volume":"341","author":[{"given":"Marcel","family":"Holzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Neugebauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Kronenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian D.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf W.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2003.12.005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04076"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2002.164"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(03)00406-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.01.036"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.21.11143-11147.2002"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5390.938"},{"key":"e_1_2_1_9_2","unstructured":"S.Ziegler B.Kronenberger S.Zeuzem R. W.Hartmann C. D.Klein unpublished results manuscript in preparation."},{"key":"e_1_2_1_10_2","first-page":"1595","volume":"8","author":"Francesco F.","year":"1970","journal-title":"J. Chem. Soc."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo9604301"},{"key":"e_1_2_1_12_2","unstructured":"L. M.Gaster H. K.Rami P. A.Wyman(Smithkline Beecham PLC UK) WO 9850358.1998."},{"key":"e_1_2_1_13_2","unstructured":"L. H.Sarett W. C.Ruyle(Merck & Co Inc) DE 1801303.1967."},{"key":"e_1_2_1_14_2","first-page":"829831","volume":"6","author":"Gong Y.","year":"2000","journal-title":"Syn. Lett."},{"key":"e_1_2_1_15_2","unstructured":"(Ciba Ltd) NL 6414307.1965."},{"key":"e_1_2_1_16_2","unstructured":"W. J.Coates A. D.Rawlings(Smithkline Beecham PLC UK) WO 9429277.1994."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570210654"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200501400"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.200700261","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.200700261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T18:49:09Z","timestamp":1697654949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.200700261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,11]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1002\/ardp.200700261"],"URL":"https:\/\/doi.org\/10.1002\/ardp.200700261","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,11]]}}}