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These compounds contained two active anticonvulsant pharmacophores, benzothiazole and barbituric acid. Structures of the compounds were confirmed on the basis of different spectroscopic techniques. All the compounds were evaluated for their anticonvulsant activity. Three compounds<jats:bold>4c<\/jats:bold>,<jats:bold>4d<\/jats:bold>, and<jats:bold>4s<\/jats:bold>showed promising anticonvulsant activities in Maximal Electroshock Seizure test (MES) and subcutaneous pentylenetetrazole test (scPTZ). They also displayed a wide safety profile when tested for the minimal motor impairment test.<\/jats:p>","DOI":"10.1002\/ardp.200900002","type":"journal-article","created":{"date-parts":[[2009,6,29]],"date-time":"2009-06-29T16:05:43Z","timestamp":1246291543000},"page":"462-468","source":"Crossref","is-referenced-by-count":21,"title":["Benzothiazole Incorporated Barbituric Acid Derivatives: Synthesis and Anticonvulsant Screening"],"prefix":"10.1002","volume":"342","author":[{"given":"Nadeem","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waquar","family":"Ahsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200302000-00005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0223-5234(96)88238-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.03.029"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2003.08.035"},{"key":"e_1_2_1_6_2","first-page":"131","volume":"44","author":"Chulak I.","year":"1990","journal-title":"Chem. 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