{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:24:21Z","timestamp":1771035861760,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T00:00:00Z","timestamp":1300924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new series of 4\u2010hydroxycoumarin derivatives <jats:bold>3a\u2013d<\/jats:bold> was synthesized by the reaction of 3\u2010bromo\u20104\u2010hydroxy coumarin <jats:bold>1<\/jats:bold> with various heteroaldehydes <jats:bold>2a\u2013d<\/jats:bold> in good yields. The synthesized compounds were characterized on the basis of their elemental and spectral (IR, <jats:sup>1<\/jats:sup>H\u2010NMR and mass spectrometry) analysis. All target compounds were evaluated for their <jats:italic>in\u2010vitro<\/jats:italic> antimicrobial activity against <jats:italic>Streptococcus pyogenes<\/jats:italic>, methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, <jats:italic>Klebsiella pneumonia<\/jats:italic>, and <jats:italic>Escherichia coli<\/jats:italic> bacterial strains and fungal cultures of <jats:italic>Candida albicans<\/jats:italic>, <jats:italic>Aspergillus fumigatus<\/jats:italic>, <jats:italic>Trichophyton mentagrophytes<\/jats:italic>, and <jats:italic>Penicillium marneffei<\/jats:italic> by disk diffusion assay with slight modifications. The minimum inhibitory concentration (MIC) was determined for the test compounds as well as for reference standards. Among the tested compounds, <jats:bold>3a<\/jats:bold> has shown the most potent antibacterial as well as antifungal activities.<\/jats:p>","DOI":"10.1002\/ardp.201000218","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T06:46:48Z","timestamp":1300949208000},"page":"394-401","source":"Crossref","is-referenced-by-count":20,"title":["Synthesis of 4\u2010Hydroxycoumarin Heteroarylhybrids as Potential Antimicrobial Agents"],"prefix":"10.1002","volume":"344","author":[{"given":"Zeba N.","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Musthafa","family":"T. 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