{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:41:54Z","timestamp":1784349714746,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T00:00:00Z","timestamp":1294963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schiff base transition metal complexes are an important class of compounds with great potential for therapeutic interventions. However, data on antileukemic and antilymphoma effects of these complexes are limited. The activity of <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032\u2010bis(salicylidene)\u20101,2\u2010phenylenediamine (salophene, <jats:bold>1<\/jats:bold>), its iron(II\/III) and manganese(II\/III) complexes as well as <jats:italic>rac<\/jats:italic>\u2010trans\u2010<jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032\u2010bis(salicylidene)\u20101,2\u2010cyclohexanediamine (saldach, <jats:bold>2<\/jats:bold>) and its respective iron(II\/III) complexes was evaluated against U\u2010937 non\u2010Hodgkin's lymphoma and the HL\u201060, SUP\u2010B15, and K\u2010562 leukemia cell lines. The free ligands induced in all cell lines, if at all, only marginal, concentration\u2010dependent growth inhibitory effects, and did not trigger Cu\/Zn superoxide dismutase (Cu\/Zn SOD) release or induce apoptosis. [Fe<jats:sup>II<\/jats:sup>(salophene)] (<jats:bold>3<\/jats:bold>) and [Fe<jats:sup>III<\/jats:sup>(salophene)Cl] (<jats:bold>4<\/jats:bold>) blocked cellular growth, caused a strong release of Cu\/Zn SOD and induced apoptosis. In contrast, the manganese analogs [Mn<jats:sup>II<\/jats:sup>(salophene)] (<jats:bold>5<\/jats:bold>) and [Mn<jats:sup>III<\/jats:sup>(salophene)OAc] (<jats:bold>6<\/jats:bold>) inhibited cell growth, caused the programmed cell death only at higher concentrations and did not provoke release of Cu\/Zn SOD in any of the four cell lines. Weaker cell death\u2010promoting effects were observed when the salophene moiety of <jats:bold>3<\/jats:bold> and <jats:bold>4<\/jats:bold> was replaced with saldach (complexes <jats:bold>7<\/jats:bold> and <jats:bold>8<\/jats:bold>), indicating the influence exerted by the ligand structure. In conclusion, Schiff base transition metal complexes induce strong inhibitory effects on human lymphoma and leukemia cells.<\/jats:p>","DOI":"10.1002\/ardp.201000237","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T15:38:33Z","timestamp":1295019513000},"page":"217-223","source":"Crossref","is-referenced-by-count":21,"title":["Effects of Metal Salophene and Saldach Complexes on Lymphoma and Leukemia 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