{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:33:31Z","timestamp":1770435211762,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T00:00:00Z","timestamp":1331596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new spirocyclophosphazene, 2,2\u2010bis(2\u2010formylphenoxy)\u20104,4,6,6\u2010bis[spiro(2\u2032,2\u2033\u2010dioxy\u20101\u2032\u20101\u2033\u2010biphenylyl)]cyclotriphosphazene (<jats:bold>3<\/jats:bold>), was obtained from the reaction of 2,2\u2010dichloro\u20104,4,6,6\u2010bis[spiro(2\u2032,2\u2033\u2010dioxy\u20101\u2032\u20101\u2033\u2010biphenylyl)]cyclotriphosphazene (<jats:bold>2<\/jats:bold>) with 2\u2010hydroxybenzaldehyde. New phosphazene derivatives bearing Schiff base and dioxybiphenyl groups have been synthesized by the reactions of <jats:bold>3<\/jats:bold> with different amines. The structures of the compounds were defined by elemental analysis, IR, <jats:sup>1<\/jats:sup>H, <jats:sup>13<\/jats:sup>C, and <jats:sup>31<\/jats:sup>P NMR spectroscopy. All the synthesized compounds were screened for their antibacterial activity against both types of Gram\u2010negative and Gram\u2010positive bacteria. The most potent antibacterial compound of this series was compound <jats:bold>12<\/jats:bold> which has the low MIC value of 3.75\u20130.9375\u2009\u00b5g<jats:bold>\/<\/jats:bold>mL. Both minimal inhibitory concentrations (MIC) and inhibition zones were determined in order to monitor the efficacy of the synthesized compounds. New compounds were also screened for anticonvulsant, CNS depressant, and sedative\u2010hypnotic activity. After i.p. injection to mice at doses of 30, 100, and 300\u2009mg\/kg body weight phosphazenes were examined in the maximal electroshock\u2010induced seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. Compounds <jats:bold>4<\/jats:bold>, <jats:bold>5<\/jats:bold>, and <jats:bold>11<\/jats:bold> were found to be active in both MES screen and scPTZ screen at 0.5\u2009h. All except <jats:bold>12<\/jats:bold> showed more than 44% decrease in locomotor activity after 1\u2009h of compound administration via actophotometer screen. CNS\u2010depressant activity screened with the help of the forced swim method resulted in some potent compounds. Except for <jats:bold>7<\/jats:bold> and <jats:bold>12<\/jats:bold> other tested compounds were found to exhibit potent CNS depressants activity as indicated by increased immobility time.<\/jats:p>","DOI":"10.1002\/ardp.201100412","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T13:52:49Z","timestamp":1331646769000},"page":"476-485","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis, Characterization, and Biological\u2013Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups"],"prefix":"10.1002","volume":"345","author":[{"given":"Erol","family":"Cil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Tanyildizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furkan","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Boybay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Orhan","family":"Gorgulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","volume-title":"Phosphorus\u2013Nitrogen Compounds","author":"Allcock H. 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