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The acute neurological toxicity was determined applying the rotarod screen. The results in mice showed that 13 compounds were effective in the MES or\/and<jats:italic>sc<\/jats:italic>PTZ screen. From these, seven molecules were tested in the MES seizures after oral administration in rats. The quantitative studies showed that<jats:italic>N<\/jats:italic>\u2010[{4\u2010(2\u2010hydroxyethyl)\u2010piperazin\u20101\u2010yl}\u2010methyl]\u20103\u2010methyl\u20103\u2010phenylpyrrolidine\u20102,5\u2010dione (<jats:bold>6c<\/jats:bold>) and<jats:italic>N<\/jats:italic>\u2010[(4\u2010benzylpiperidin\u20101\u2010yl)\u2010methyl]\u20103\u2010methyl\u20103\u2010phenylpyrrolidine\u20102,5\u2010dione (<jats:bold>6f<\/jats:bold>) revealed higher protection in the MES and<jats:italic>sc<\/jats:italic>PTZ tests than valproic acid or ethosuximide which were used as reference antiepileptic drugs. Four compounds (<jats:bold>5c<\/jats:bold>,<jats:bold>6c<\/jats:bold>,<jats:bold>6e<\/jats:bold>,<jats:bold>6f<\/jats:bold>) showed high effectiveness in the 6\u2010Hz psychomotor seizure model of partial and therapy resistant epilepsy.<\/jats:p>","DOI":"10.1002\/ardp.201200092","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T11:54:17Z","timestamp":1338983657000},"page":"713-722","source":"Crossref","is-referenced-by-count":20,"title":["Synthesis and Anticonvulsant Properties of New Mannich Bases Derived from 3,3\u2010Disubstituted Pyrrolidine\u20102,5\u2010diones. 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